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. 1989 Oct;30(10):1401–1405. doi: 10.1136/gut.30.10.1401

Comparison of albendazole, mebendazole and praziquantel chemotherapy of Echinococcus multilocularis in a gerbil model.

D H Taylor 1, D L Morris 1, D Reffin 1, K S Richards 1
PMCID: PMC1434421  PMID: 2583567

Abstract

The efficacy of albendazole (50 mg/kg/d), mebendazole (50 mg/kg/d) and praziquantel (500 mg/kg/d) against established intraperitoneal infections of Echinococcus multilocularis in gerbils was compared by monitoring parasite weight and making ultrastructural observations on treated and untreated material. Praziquantel was the most active protoscolicidal agent, reducing protoscolex viability to less than 2%, although it did not inhibit cyst growth. Albendazole was the most effective agent in reducing cyst growth and was, when compared with other regimes significantly more effective than mebendazole (p less than 0.05), praziquantel (p less than 0.01) or untreated controls (p less than 0.01).

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Davis A., Pawlowski Z. S., Dixon H. Multicentre clinical trials of benzimidazolecarbamates in human echinococcosis. Bull World Health Organ. 1986;64(3):383–388. [PMC free article] [PubMed] [Google Scholar]
  2. Eckert J., Burkhardt B. Chemotherapy of experimental echinococcosis. Acta Trop. 1980 Sep;37(3):297–300. [PubMed] [Google Scholar]
  3. Kern P. Human echinococcosis: follow-up of 23 patients treated with mebendazole. Infection. 1983 Jan-Feb;11(1):17–24. doi: 10.1007/BF01651352. [DOI] [PubMed] [Google Scholar]
  4. Luder P. J., Robotti G., Meister F. P., Bircher J. High oral doses of mebendazole interfere with growth of larval Echinococcus multilocularis lesions. J Hepatol. 1985;1(4):369–377. doi: 10.1016/s0168-8278(85)80774-1. [DOI] [PubMed] [Google Scholar]
  5. Mosimann F. Is alveolar hydatid disease of the liver incurable? Ann Surg. 1980 Jul;192(1):118–123. doi: 10.1097/00000658-198007000-00021. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Rausch R. L., Wilson J. F., McMahon B. J., O'Gorman M. A. Consequences of continuous mebendazole therapy in alveolar hydatid disease--with a summary of a ten-year clinical trial. Ann Trop Med Parasitol. 1986 Aug;80(4):403–419. doi: 10.1080/00034983.1986.11812041. [DOI] [PubMed] [Google Scholar]
  7. Richards K. S., Morris D. L., Daniels D., Riley E. M. Echinococcus granulosus: the effects of praziquantel, in vivo and in vitro, on the ultrastructure of equine strain murine cysts. Parasitology. 1988 Apr;96(Pt 2):323–336. doi: 10.1017/s0031182000058327. [DOI] [PubMed] [Google Scholar]
  8. Schröder R., Robotti G. New aspects in the management of alveolar echinococcosis involving the liver. World J Surg. 1986 Dec;10(6):968–973. doi: 10.1007/BF01658648. [DOI] [PubMed] [Google Scholar]
  9. Taylor D. H., Morris D. L. In vitro culture of Echinococcus multilocularis: protoscolicidal action of praziquantel and albendazole sulphoxide. Trans R Soc Trop Med Hyg. 1988;82(2):265–267. doi: 10.1016/0035-9203(88)90443-9. [DOI] [PubMed] [Google Scholar]
  10. Taylor D. H., Morris D. L., Richards K. S., Reffin D. Echinococcus multilocularis: in vivo results of therapy with albendazole and praziquantel. Trans R Soc Trop Med Hyg. 1988;82(4):611–615. doi: 10.1016/0035-9203(88)90528-7. [DOI] [PubMed] [Google Scholar]
  11. Wilson J. F., Rausch R. L., McMahon B. J., Schantz P. M., Trujillo D. E., O'Gorman M. A. Albendazole therapy in alveolar hydatid disease: a report of favorable results in two patients after short-term therapy. Am J Trop Med Hyg. 1987 Jul;37(1):162–168. doi: 10.4269/ajtmh.1987.37.162. [DOI] [PubMed] [Google Scholar]
  12. Wilson J. F., Rausch R. L. Mebendazole and alveolar hydatid disease. Ann Trop Med Parasitol. 1982 Apr;76(2):165–173. doi: 10.1080/00034983.1982.11687523. [DOI] [PubMed] [Google Scholar]

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