Skip to main content
PMC home page
Gut logoLink to Gut
. 1987;28(Suppl):249–251. doi: 10.1136/gut.28.suppl.249

Augmentation of chemically induced pancreatic and bronchial cancers by epidermal growth factor.

R A Malt 1, J F Chester 1, H A Gaissert 1, J S Ross 1
PMCID: PMC1434533  PMID: 3319811

Abstract

The incidence of Syrian golden hamsters with pancreatic cancer induced by subcutaneous injections of N-nitroso-bis(2-oxopropyl)amine for 19 weeks (each 10 mg/kg) increased from 44% to 75% (p=0.016) when epidermal growth factor was also administered from week 5 through week 8 (5 mug energy three days for injections). Epidermal growth factor increased pancreatic weight and body weight. The incidence of animals with bronchial cancer doubled. Epidermal growth factor could be a cocarcinogen as a result of its mitogenic activity.

Full text

PDF
249

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Andrén-Sandberg A., Dawiskiba S., Ihse I. Studies of the effect of cerulein administration on experimental pancreatic carcinogenesis. Scand J Gastroenterol. 1984 Jan;19(1):122–128. [PubMed] [Google Scholar]
  2. Bristol J. B., Wells M., Williamson R. C. Adaptation to jejunoileal bypass promotes experimental colorectal carcinogenesis. Br J Surg. 1984 Feb;71(2):123–126. doi: 10.1002/bjs.1800710216. [DOI] [PubMed] [Google Scholar]
  3. Chester J. F., Gaissert H. A., Ross J. S., Malt R. A. Pancreatic cancer in the Syrian hamster induced by N-nitrosobis(2-oxopropyl)-amine: cocarcinogenic effect of epidermal growth factor. Cancer Res. 1986 Jun;46(6):2954–2957. [PubMed] [Google Scholar]
  4. Clark A. J., Ishii S., Richert N., Merlino G. T., Pastan I. Epidermal growth factor regulates the expression of its own receptor. Proc Natl Acad Sci U S A. 1985 Dec;82(24):8374–8378. doi: 10.1073/pnas.82.24.8374. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Cubilla A. L., Fitzgerald P. J. Classification of pancreatic cancer (nonendocrine). Mayo Clin Proc. 1979 Jul;54(7):449–458. [PubMed] [Google Scholar]
  6. Downward J., Yarden Y., Mayes E., Scrace G., Totty N., Stockwell P., Ullrich A., Schlessinger J., Waterfield M. D. Close similarity of epidermal growth factor receptor and v-erb-B oncogene protein sequences. Nature. 1984 Feb 9;307(5951):521–527. doi: 10.1038/307521a0. [DOI] [PubMed] [Google Scholar]
  7. Earp H. S., Austin K. S., Blaisdell J., Rubin R. A., Nelson K. G., Lee L. W., Grisham J. W. Epidermal growth factor (EGF) stimulates EGF receptor synthesis. J Biol Chem. 1986 Apr 15;261(11):4777–4780. [PubMed] [Google Scholar]
  8. Goustin A. S., Leof E. B., Shipley G. D., Moses H. L. Growth factors and cancer. Cancer Res. 1986 Mar;46(3):1015–1029. [PubMed] [Google Scholar]
  9. Hierowski M. T., Liebow C., du Sapin K., Schally A. V. Stimulation by somatostatin of dephosphorylation of membrane proteins in pancreatic cancer MIA PaCa-2 cell line. FEBS Lett. 1985 Jan 7;179(2):252–256. doi: 10.1016/0014-5793(85)80529-9. [DOI] [PubMed] [Google Scholar]
  10. Howatson A. G., Carter D. C. Pancreatic carcinogenesis-enhancement by cholecystokinin in the hamster-nitrosamine model. Br J Cancer. 1985 Jan;51(1):107–114. doi: 10.1038/bjc.1985.15. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Ishikawa O., Wada A., Oohigashi H., Imaoka S., Iwanaga T. Relationship between goblet cells and carcinoma of the pancreas during N-nitrosobis(2-hydroxypropyl)amine-induced carcinogenesis in Syrian golden hamsters. Cancer Res. 1984 Apr;44(4):1630–1634. [PubMed] [Google Scholar]
  12. Kingsnorth A. N., Abu-Khalaf M., Ross J. S., Malt R. A. Potentiation of 1,2-dimethylhydrazine-induced anal carcinoma by epidermal growth factor in mice. Surgery. 1985 Jun;97(6):696–700. [PubMed] [Google Scholar]
  13. Kokkinakis D. M., Scarpelli D. G., Rao M. S., Hollenberg P. F. Metabolism of pancreatic carcinogens N-nitroso-2,6-dimethylmorpholine and N-nitrosobis(2-oxopropyl)amine by microsomes and cytosol of hamster pancreas and liver. Cancer Res. 1983 Dec;43(12 Pt 1):5761–5767. [PubMed] [Google Scholar]
  14. Korc M., Magun B. E. Recycling of epidermal growth factor in a human pancreatic carcinoma cell line. Proc Natl Acad Sci U S A. 1985 Sep;82(18):6172–6175. doi: 10.1073/pnas.82.18.6172. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Lew E. A., Garfinkel L. Variations in mortality by weight among 750,000 men and women. J Chronic Dis. 1979;32(8):563–576. doi: 10.1016/0021-9681(79)90119-x. [DOI] [PubMed] [Google Scholar]
  16. Pour P. M., Runge R. G., Birt D., Gingell R., Lawson T., Nagel D., Wallcave L., Salmasi S. Z. Current knowledge of pancreatic carcinogenesis in the hamster and its relevance to the human disease. Cancer. 1981 Mar 15;47(6 Suppl):1573–1589. doi: 10.1002/1097-0142(19810315)47:6+<1573::aid-cncr2820471420>3.0.co;2-k. [DOI] [PubMed] [Google Scholar]
  17. Rall L. B., Scott J., Bell G. I., Crawford R. J., Penschow J. D., Niall H. D., Coghlan J. P. Mouse prepro-epidermal growth factor synthesis by the kidney and other tissues. Nature. 1985 Jan 17;313(5999):228–231. doi: 10.1038/313228a0. [DOI] [PubMed] [Google Scholar]
  18. Rose S. P., Stahn R., Passovoy D. S., Herschman H. Epidermal growth factor enhancement of skin tumor induction in mice. Experientia. 1976;32(7):913–915. doi: 10.1007/BF02003764. [DOI] [PubMed] [Google Scholar]
  19. Rotstein J., Sarma D. S., Farber E. Sequential alterations in growth control and cell dynamics of rat hepatocytes in early precancerous steps in hepatocarcinogenesis. Cancer Res. 1986 May;46(5):2377–2385. [PubMed] [Google Scholar]
  20. Scarpelli D. G., Rao M. S., Subbarao V. Augmentation of carcinogenesis by N-nitrosobis(2-oxopropyl)amine administered during S phase of the cell cycle in regenerating hamster pancreas. Cancer Res. 1983 Feb;43(2):611–616. [PubMed] [Google Scholar]
  21. Sporn M. B., Roberts A. B. Autocrine growth factors and cancer. 1985 Feb 28-Mar 6Nature. 313(6005):745–747. doi: 10.1038/313745a0. [DOI] [PubMed] [Google Scholar]
  22. Stoscheck C. M., King L. E., Jr Role of epidermal growth factor in carcinogenesis. Cancer Res. 1986 Mar;46(3):1030–1037. [PubMed] [Google Scholar]
  23. Takeuchi T., Gumucio D. L., Yamada T., Meisler M. H., Minth C. D., Dixon J. E., Eddy R. E., Shows T. B. Genes encoding pancreatic polypeptide and neuropeptide Y are on human chromosomes 17 and 7. J Clin Invest. 1986 Mar;77(3):1038–1041. doi: 10.1172/JCI112357. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Townsend C. M., Jr, Franklin R. B., Gelder F. B., Glass E., Thompson J. C. Development of a transplantable model of pancreatic duct adenocarcinoma. Surgery. 1982 Jul;92(1):72–78. [PubMed] [Google Scholar]
  25. Wakshull E. M., Wharton W. Stabilized complexes of epidermal growth factor and its receptor on the cell surface stimulate RNA synthesis but not mitogenesis. Proc Natl Acad Sci U S A. 1985 Dec;82(24):8513–8517. doi: 10.1073/pnas.82.24.8513. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. Weinberg R. A. The action of oncogenes in the cytoplasm and nucleus. Science. 1985 Nov 15;230(4727):770–776. doi: 10.1126/science.2997917. [DOI] [PubMed] [Google Scholar]
  27. Williamson R. C., Bauer F. L., Terpstra O. T., Ross J. S., Malt R. A. Contrasting effects of subtotal enteric bypass, enterectomy, and colectomy on azoxymethane-induced intestinal carcinogenesis. Cancer Res. 1980 Mar;40(3):538–543. [PubMed] [Google Scholar]

Articles from Gut are provided here courtesy of BMJ Publishing Group

RESOURCES