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. 1987;28(Suppl):15–17. doi: 10.1136/gut.28.suppl.15

Growth stimulating activity associated with an altered cell renewal pattern in the small intestine.

V L Grey 1, J M Kenscoff 1, C L Morin 1
PMCID: PMC1434536  PMID: 3692301

Abstract

A growth stimulating activity has been recently identified in the rat proximal intestine during the transient stages of adaptation after small bowel resection. This study shows that the growth stimulating activity is associated with all the cells of the crypt-villus axis. At the same time the thymidine kinase activity is detectable in all the cells implying a more extensive proliferative zone during the transient stages of adaptation. The presence of the growth stimulating activity along with the more extensive proliferative zone suggests that the activity modulates the proliferation capacity of intestinal epithelial cells.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BREITMAN T. R. The feedback inhibition of thymidine kinase. Biochim Biophys Acta. 1963 Jan 8;67:153–155. doi: 10.1016/0006-3002(63)91807-9. [DOI] [PubMed] [Google Scholar]
  2. Eichholz A. Structural and functional organization of the brush border of intestinal epithelial cells. 3. Enzymic activities and chemical composition of various fractions of tris-disrupted brush borders. Biochim Biophys Acta. 1967 Jul 3;135(3):475–482. doi: 10.1016/0005-2736(67)90037-5. [DOI] [PubMed] [Google Scholar]
  3. Fortin-Magana R., Hurwitz R., Herbst J. J., Kretchmer N. Intestinal enzymes: indicators of proliferation and differentiation in the jejunum. Science. 1970 Mar 20;167(3925):1627–1628. doi: 10.1126/science.167.3925.1627. [DOI] [PubMed] [Google Scholar]
  4. Grey V. L., Morin C. L. Evidence for a growth-stimulating fraction in the rat proximal intestine after small bowel resection. Gastroenterology. 1985 Dec;89(6):1305–1312. doi: 10.1016/0016-5085(85)90647-x. [DOI] [PubMed] [Google Scholar]
  5. Klemperer H. G., Haynes G. R. Thymidine kinase in rat liver during development. Biochem J. 1968 Jul;108(4):541–546. doi: 10.1042/bj1080541. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. LOWRY O. H., ROSEBROUGH N. J., FARR A. L., RANDALL R. J. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951 Nov;193(1):265–275. [PubMed] [Google Scholar]
  7. Obertop H., Nundy S., Malamud D., Malt R. A. Onset of cell proliferation in the shortened gut. Rapid hyperplasia after jejunal resection. Gastroenterology. 1977 Feb;72(2):267–270. [PubMed] [Google Scholar]
  8. Weiser M. M. Intestinal epithelial cell surface membrane glycoprotein synthesis. I. An indicator of cellular differentiation. J Biol Chem. 1973 Apr 10;248(7):2536–2541. [PubMed] [Google Scholar]
  9. Williamson R. C. Intestinal adaptation (first of two parts). Structural, functional and cytokinetic changes. N Engl J Med. 1978 Jun 22;298(25):1393–1402. doi: 10.1056/NEJM197806222982505. [DOI] [PubMed] [Google Scholar]

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