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. 1984 Jun;45(6):1101–1107. doi: 10.1016/S0006-3495(84)84258-7

Effect of pore structure on energy barriers and applied voltage profiles. II. Unsymmetrical channels.

P C Jordan
PMCID: PMC1435004  PMID: 6331540

Abstract

This paper examines "realistic" pores, i.e., ones that are neither symmetric nor of uniform diameter. Methods are described that permit estimation of the image potential for an ion in an aqueous pore spanning a lipid membrane and for the electric field produced in such a pore when a transmembrane potential is applied. They are used to model features of the delayed rectifier potassium channel. Constraints on the geometry of the exterior mouth, the dielectric properties of the narrow part of the pore and the conduction mechanism are determined for this channel.

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Selected References

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