Abstract
Methods of diagnosis and anatomical localization of cerebral neoplasms have reached a high level of efficiency. A new method of studying cerebral circulation and metabolism by a simple noninvasive technique of steady-state imaging during the inhalation of radioactive oxygen and radioactive oxygen-labelled CO2 is described. The results of preliminary studies of a group of cerebral neoplasms of various histological types are presented and the implications discussed.
Full text
PDF
Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Allen N. Oxidative metabolism of brain tumors. Prog Exp Tumor Res. 1972;17:192–209. doi: 10.1159/000393674. [DOI] [PubMed] [Google Scholar]
- Alpert N. M., Ackerman R. H., Correia J. A., Baron J. C., Brownell G. L., Taveras J. M. Measurement of rCBE and rCMRO2 by continuous inhalation of 15O-labeled CO2 and O2. Acta Neurol Scand Suppl. 1977;64:186–187. [PubMed] [Google Scholar]
- Endo H., Larsen B., Lassen N. A. Regional cerebral blood flow alterations remote from the site of intracranial tumors. J Neurosurg. 1977 Mar;46(3):271–281. doi: 10.3171/jns.1977.46.3.0271. [DOI] [PubMed] [Google Scholar]
- Jones T., Chesler D. A., Ter-Pogossian M. M. The continuous inhalation of oxygen-15 for assessing regional oxygen extraction in the brain of man. Br J Radiol. 1976 Apr;49(580):339–343. doi: 10.1259/0007-1285-49-580-339. [DOI] [PubMed] [Google Scholar]
- Lassen N. A. The luxury-perfusion syndrome and its possible relation to acute metabolic acidosis localised within the brain. Lancet. 1966 Nov 19;2(7473):1113–1115. doi: 10.1016/s0140-6736(66)92199-4. [DOI] [PubMed] [Google Scholar]
- Lenzi G. L., Jones T., McKenzie C. G., Buckingham P. D., Clark J. C., Moss S. Study of regional cerebral metabolism and blood flow relationships in man using the method of continuously inhaling oxygen-15 and oxygen-15 labelled carbon dioxide. J Neurol Neurosurg Psychiatry. 1978 Jan;41(1):1–10. doi: 10.1136/jnnp.41.1.1. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lenzi G. L., Jones T., McKenzie C. G., Moss S. Non-invasive regional study of chronic cerebrovascular disorders using the oxygen-15 inhalation technique. J Neurol Neurosurg Psychiatry. 1978 Jan;41(1):11–17. doi: 10.1136/jnnp.41.1.11. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lenzi G. L., Jones T., Moss S. The relationship between regional oxygen utilization and cerebral blood flow in multi-infarct dementia. Acta Neurol Scand Suppl. 1977;64:248–249. [PubMed] [Google Scholar]
- Lenzi G. L., Jones T., Reid J., Moss S. Non-invasive study of the metabolism-to-blood flow relationship in Parkinson's disease. Acta Neurol Scand Suppl. 1977;64:184–185. [PubMed] [Google Scholar]
- McKenzie C. C., Jones T., Lenzi G. L., Moss S. Oxygen-15 by inhalation in the investigation of cerebral neoplasms. Acta Neurol Scand Suppl. 1977;64:182–183. [PubMed] [Google Scholar]
- Pinching A. J., Travers R. L., Hughes G. R., Jones T., Moss S. Oxygen-15 brain scanning for detection of cerebral involvement in systemic lupus erythematosus. Lancet. 1978 Apr 29;1(8070):898–900. doi: 10.1016/s0140-6736(78)90680-3. [DOI] [PubMed] [Google Scholar]
- WEST J. B., DOLLERY C. T. Uptake of oxygen-15-labeled CO2 compared with carbon-11-labeled CO2 in the lung. J Appl Physiol. 1962 Jan;17:9–13. doi: 10.1152/jappl.1962.17.1.9. [DOI] [PubMed] [Google Scholar]
- Westerman B. R., Glass H. I. Physical specification of a gamma camera. J Nucl Med. 1968 Jan;9(1):24–30. [PubMed] [Google Scholar]