Skip to main content
Journal of the Royal Society of Medicine logoLink to Journal of the Royal Society of Medicine
. 1979 Apr;72(4):266–269. doi: 10.1177/014107687907200407

Lymphocyte purine metabolism -- significance of 5'-nucleotidase deficiency: a review.

A D Webster, N Matamoros
PMCID: PMC1437037  PMID: 233249

Full text

PDF
266

Images in this article

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Allison A. C., Hovi T., Watts R. W., Webster A. D. Immunological observations on patients with Lesch-Nyhan syndrome, and on the role of de-novo purine synthesis in lymphocyte transformation. Lancet. 1975 Dec 13;2(7946):1179–1183. doi: 10.1016/s0140-6736(75)92661-6. [DOI] [PubMed] [Google Scholar]
  2. Berlin R. D., Oliver J. M. Membrane transport of purine and pyrimidine bases and nucleosides in animal cells. Int Rev Cytol. 1975;42:287–336. doi: 10.1016/s0074-7696(08)60983-3. [DOI] [PubMed] [Google Scholar]
  3. Carson D. A., Kaye J., Seegmiller J. E. Lymphospecific toxicity in adenosine deaminase deficiency and purine nucleoside phosphorylase deficiency: possible role of nucleoside kinase(s). Proc Natl Acad Sci U S A. 1977 Dec;74(12):5677–5681. doi: 10.1073/pnas.74.12.5677. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Evans W. H., Gurd J. W. Properties of a 5'-nucleotidase purified from mouse liver plasma membranes. Biochem J. 1973 May;133(1):189–199. doi: 10.1042/bj1330189. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Giblett E. R., Ammann A. J., Wara D. W., Sandman R., Diamond L. K. Nucleoside-phosphorylase deficiency in a child with severely defective T-cell immunity and normal B-cell immunity. Lancet. 1975 May 3;1(7914):1010–1013. doi: 10.1016/s0140-6736(75)91950-9. [DOI] [PubMed] [Google Scholar]
  6. Johnson S. M., North M. E., Asherson G. L., Allsop J., Watts R. W., Webster A. D. Lymphocyte purine 5'-nucleotidase edficiency in primary hypogammaglobulinaemia. Lancet. 1977 Jan 22;1(8004):168–170. doi: 10.1016/s0140-6736(77)91765-2. [DOI] [PubMed] [Google Scholar]
  7. O'Dorisio M. S., Neidhart J. A., Daniel F. B., Balcerzak S. P., LoBuglio A. F. Identification of hypoxanthine as the major compoenet of a chromatographic fraction of transfer factor. Cell Immunol. 1976 May;23(2):191–202. doi: 10.1016/0008-8749(76)90185-4. [DOI] [PubMed] [Google Scholar]
  8. Polmar S. H. Lymphocyte enzyme deficiencies and the metabolic basis of immunodeficiency disease. Clin Haematol. 1977 Jun;6(2):423–438. [PubMed] [Google Scholar]
  9. Polmar S. H., Stern R. C., Schwartz A. L., Wetzler E. M., Chase P. A., Hirschhorn R. Enzyme replacement therapy for adenosine deaminase deficiency and severe combined immunodeficiency. N Engl J Med. 1976 Dec 9;295(24):1337–1343. doi: 10.1056/NEJM197612092952402. [DOI] [PubMed] [Google Scholar]
  10. Quagliata F., Faig D., Conklyn M., Silber R. Studies on the lymphocyte 5'-nucleotidase in chronic lymphocytic leukemia, infectious mononucleosis, normal subpopulations, and phytohemagglutinin-stimulated cells. Cancer Res. 1974 Dec;34(12):3197–3202. [PubMed] [Google Scholar]
  11. Rodan G. A., Bourret L. A., Cutler L. S. Membrane changes during cartilage maturation. Increase in 5'-nucleotidase and decrease in adenosine inhibition of adenylate cyclase. J Cell Biol. 1977 Feb;72(2):493–501. doi: 10.1083/jcb.72.2.493. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Shenoy T. S., Clifford A. J. Adenine nucleotide metabolism in relation to purine enzymes in liver, erythrocytes and cultured fibroblasts. Biochim Biophys Acta. 1975 Nov 10;411(1):133–143. doi: 10.1016/0304-4165(75)90292-5. [DOI] [PubMed] [Google Scholar]
  13. Silber R., Conklyn M., Grusky G., Zucker-Franklin D. Human lymphocytes: 5'-nucleotidase-positive and -negative subpopulations. J Clin Invest. 1975 Nov;56(5):1324–1327. doi: 10.1172/JCI108209. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Stoop J. W., Zegers B. J., Hendrickx G. F., van Heukelom L. H., Staal G. E., de Bree P. K., Wadman S. K., Ballieux R. E. Purine nucleoside phosphorylase deficiency associated with selective cellular immunodeficiency. N Engl J Med. 1977 Mar 24;296(12):651–655. doi: 10.1056/NEJM197703242961203. [DOI] [PubMed] [Google Scholar]
  15. Uusitalo R. J., Karnovsky M. J. Surface localization of 5'-nucleotidase on the mouse lymphocyte. J Histochem Cytochem. 1977 Feb;25(2):87–96. doi: 10.1177/25.2.14210. [DOI] [PubMed] [Google Scholar]
  16. Webster A. D., North M., Allsop J., Asherson G. L., Watts R. W. Purine metabolism in lymphocytes from patients with primary hypogammaglobulinaemia. Clin Exp Immunol. 1978 Mar;31(3):456–463. [PMC free article] [PubMed] [Google Scholar]

Articles from Journal of the Royal Society of Medicine are provided here courtesy of Royal Society of Medicine Press

RESOURCES