Skip to main content
Journal of the Royal Society of Medicine logoLink to Journal of the Royal Society of Medicine
. 1981 May;74(5):357–362.

Captopril for refractory hypertension in patients with chronic renal failure and renal transplantation.

D V Hamilton, D B Evans, G Maidment, J S Pryor
PMCID: PMC1438816  PMID: 7017137

Abstract

The converting-enzyme inhibitor, captopril, was given to ten patients with refractory severe hypertension of renal origin: 6 patients had chronic renal failure, 3 patients had hypertension following renal transplantation, and one patient had hypertension and congestive cardiac failure. Control of blood pressure was achieved with doses from 78 to 400 mg/day. Severe hyperkalaemia occurred in one patients, ageusia (dose dependent) in another, and one patients withdrew from treatment because of nausea.

Full text

PDF
357

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Atkinson A. B., Brown J. J., Lever A. F., Robertson J. I. Combined treatment of severe intractable hypertension with captopril and diuretic. Lancet. 1980 Jul 19;2(8186):105–108. doi: 10.1016/s0140-6736(80)90001-x. [DOI] [PubMed] [Google Scholar]
  2. Atlas S. A., Case D. B., Sealey J. E., Laragh J. H., McKinstry D. N. Interruption of the renin-angiotensin system in hypertensive patients by captopril induces sustained reduction in aldosterone secretion, potassium retention and natruiresis. Hypertension. 1979 May-Jun;1(3):274–280. doi: 10.1161/01.hyp.1.3.274. [DOI] [PubMed] [Google Scholar]
  3. Bravo E. L., Tarazi R. C. Converting enzyme inhibition with an orally active compound in hypertensive man. Hypertension. 1979 Jan-Feb;1(1):39–46. doi: 10.1161/01.hyp.1.1.39. [DOI] [PubMed] [Google Scholar]
  4. Brunner H. R., Waeber B., Wauters J. P., Turin G., McKinstry D., Gavras H. Innappropriate renin secretion unmasked by captopril (SQ 14 225) in hypertension of chronic renal failure. Lancet. 1978 Sep 30;2(8092 Pt 1):704–707. doi: 10.1016/s0140-6736(78)92703-4. [DOI] [PubMed] [Google Scholar]
  5. Calman K. C., Bell P. R., Briggs J. D., Hamilton D. N., MacPherson S. G., Paton A. M. Bilateral nephrectomy prior to renal transplantation. Br J Surg. 1976 Jul;63(7):512–516. doi: 10.1002/bjs.1800630704. [DOI] [PubMed] [Google Scholar]
  6. Collste P., Haglund K., Lundgren G., Magnusson G., Ostman J. Reversible renal failure during treatment with captopril. Br Med J. 1979 Sep 8;2(6190):612–613. doi: 10.1136/bmj.2.6190.612-c. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Dargie H. J., Dollery C. T., Daniel J. Minoxidil in resistant hypertension. Lancet. 1977 Sep 10;2(8037):515–518. doi: 10.1016/s0140-6736(77)90660-2. [DOI] [PubMed] [Google Scholar]
  8. Davis R., Ribner H. S., Keung E., Sonnenblick E. H., LeJemtel T. H. Treatment of chronic congestive heart failure with captopril, an oral inhibitor of angiotensin-converting enzyme. N Engl J Med. 1979 Jul 19;301(3):117–121. doi: 10.1056/NEJM197907193010301. [DOI] [PubMed] [Google Scholar]
  9. Elijovisch F., Krakoff L. R. Captopril associated granulocytopenia in hypertension after renal transplantation. Lancet. 1980 Apr 26;1(8174):927–928. doi: 10.1016/s0140-6736(80)90854-5. [DOI] [PubMed] [Google Scholar]
  10. Grossman A., Eckland D., Price P., Edwards C. R. Captopril: reversible renal failure with severe hyperkalaemia. Lancet. 1980 Mar 29;1(8170):712–712. [PubMed] [Google Scholar]
  11. Kosman M. E. Evaluation of a new antihypertensive agent. Minoxidil. JAMA. 1980 Jul 4;244(1):73–75. [PubMed] [Google Scholar]
  12. Marquez-Julio A., From G. L., Uldall P. R. Minoxidil in refractory hypertension: benefits, risks. Proc Eur Dial Transplant Assoc. 1977;14:501–508. [PubMed] [Google Scholar]
  13. Prins E. J., Donker A. J., Hoorntje S. J., Leenen F. H., van der Hem G. K. Treatment of moderate to severe hypertensive patients with an orally active converting-enzyme inhibitor. Proc Eur Dial Transplant Assoc. 1979;16:603–609. [PubMed] [Google Scholar]
  14. Prins E. J., Hoorntje S. J., Weening J. J., Donker A. J. Nephrotic syndrome in patient on captopril. Lancet. 1979 Aug 11;2(8137):306–307. doi: 10.1016/s0140-6736(79)90322-2. [DOI] [PubMed] [Google Scholar]
  15. Starzl T. E., Porter K. A., Andres G., Halgrimson C. G., Hurwitz R., Giles G., Terasaki P. I., Penn I., Schroter G. T., Lilly J. Long-term survival after renal transplantation in humans: (with special reference to histocompatibility matching, thymectomy, homograft glomerulonephritis, heterologous ALG , AND RECIPIENT MALIGNANCY). Ann Surg. 1970 Sep;172(3):437–472. doi: 10.1097/00000658-197009000-00011. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Takeda R., Morimoto S., Uchida K., Kigoshi T., Sumitani T., Matsubara F. Effects of captopril on both hypertension and proteinuria. Report of a case of renovascular hypertension associated with nephrotic syndrome. Arch Intern Med. 1980 Nov;140(11):1531–1533. [PubMed] [Google Scholar]
  17. Warren S. E., O'Connor D. T. Hyperkalemia resulting from captopril administration. JAMA. 1980 Dec 5;244(22):2551–2552. [PubMed] [Google Scholar]
  18. White N. J., Rajagopalan B., Yahaya H., Ledingham J. G. Captopril and frusemide in severe drug-resistant hypertension. Lancet. 1980 Jul 19;2(8186):108–110. doi: 10.1016/s0140-6736(80)90002-1. [DOI] [PubMed] [Google Scholar]
  19. Yarimizu S. N., Susan L. P., Straffon R. A., Stewart B. H., Magnusson M. O., Nakamoto S. S. Mortality and morbidity in pretransplant bilateral nephrectomy: analysis of 305 cases. Urology. 1978 Jul;12(1):55–58. doi: 10.1016/0090-4295(78)90367-9. [DOI] [PubMed] [Google Scholar]

Articles from Journal of the Royal Society of Medicine are provided here courtesy of Royal Society of Medicine Press

RESOURCES