Skip to main content
NCBI home page
Journal of the Royal Society of Medicine logoLink to Journal of the Royal Society of Medicine
. 1983 Jun;76(6):467–472.

Chemotherapy of chemically-induced colorectal tumours.

J M Gilbert, E M Thompson, G Slavin, A E Kark
PMCID: PMC1439211  PMID: 6864720

Abstract

Benign and malignant tumours were induced in the large bowel of rats by the carcinogen 1,2-dimethylhydrazine (DMH). Benign tumours appeared from week 20 onwards and malignant tumours from week 30. 5-Fluorouracil was administered intraperitoneally in maximally tolerated doses from week 26 onwards and failed to influence significantly the development of either benign or malignant tumours. Tumours induced by DMH are a close model of human colorectal cancer and suitable for testing anticancer drugs. Agents with greater activity against colorectal cancer are required.

Full text

PDF
467

Images in this article

470Figure 4. A
on p.470
470Figure 4. B
on p.470

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Corbett T. H., Griswold D. P., Jr, Roberts B. J., Peckham J. C., Schabel F. M., Jr Evaluation of single agents and combinations of chemotherapeutic agents in mouse colon carcinomas. Cancer. 1977 Nov;40(5 Suppl):2660–2680. doi: 10.1002/1097-0142(197711)40:5+<2660::aid-cncr2820400940>3.0.co;2-m. [DOI] [PubMed] [Google Scholar]
  2. Cruse J. P., Lewin M. R., Clark C. G. Corynebacterium parvum enhances colonic cancer in dimethylhydrazine-treated rats. Br J Cancer. 1978 Apr;37(4):639–643. doi: 10.1038/bjc.1978.94. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Davis H. L., Kisner D. L. Analysis of adjuvant therapy in large bowel cancer. Cancer Clin Trials. 1978 Winter;1(4):273–287. [PubMed] [Google Scholar]
  4. Filipe M. I. Mucous secretion in rat colonic mucosa during carcinogenesis induced by dimethylhydrazine. A morphological and histochemical study. Br J Cancer. 1975 Jul;32(1):60–77. doi: 10.1038/bjc.1975.134. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Freireich E. J., Gehan E. A., Rall D. P., Schmidt L. H., Skipper H. E. Quantitative comparison of toxicity of anticancer agents in mouse, rat, hamster, dog, monkey, and man. Cancer Chemother Rep. 1966 May;50(4):219–244. [PubMed] [Google Scholar]
  6. Gilbert J. M. Adjuvant chemotherapy of large bowel cancer. Cancer Treat Rev. 1982 Sep;9(3):195–228. doi: 10.1016/s0305-7372(82)80007-8. [DOI] [PubMed] [Google Scholar]
  7. Goodwin W., Stephens R., McCracken J. D., Groppe C. Therapy for advanced colorectal cancer with a combination of 5-FU and anguidine: a Southwest Oncology Group Study. Cancer Treat Rep. 1981 Mar-Apr;65(3-4):359–359. [PubMed] [Google Scholar]
  8. LaMont J. T., O'Gorman T. A. Experimental colon cancer. Gastroenterology. 1978 Dec;75(6):1157–1169. [PubMed] [Google Scholar]
  9. Mackman S., Ansfield F. J., Ramirez G., Curreri A. R. A second look at the second operation in colonic cancer after the administration of fluorouracil. Am J Surg. 1974 Dec;128(6):763–766. doi: 10.1016/0002-9610(74)90066-x. [DOI] [PubMed] [Google Scholar]
  10. Mackman S., Curreri A. R., Ansfield F. J. Second-look operation for colon carcinoma after fluorouracil therapy. Arch Surg. 1970 Apr;100(4):527–531. doi: 10.1001/archsurg.1970.01340220203034. [DOI] [PubMed] [Google Scholar]
  11. Moertel C. G. Chemotherapy of gastrointestinal cancer. N Engl J Med. 1978 Nov 9;299(19):1049–1052. doi: 10.1056/NEJM197811092991906. [DOI] [PubMed] [Google Scholar]
  12. Moertel C. G. Chemotherapy of gastrointestinal cancer. Clin Gastroenterol. 1976 Sep;5(3):777–793. [PubMed] [Google Scholar]
  13. Narisawa T., Kohno K. I., Yamaguchi T., Takahashi T. Chemoprevention of development of colonic adenomatosis and carcinomatosis with intrarectal dose of 5-FU on animal model. Cancer. 1980 Feb;45(3):439–443. doi: 10.1002/1097-0142(19800201)45:3<439::aid-cncr2820450306>3.0.co;2-p. [DOI] [PubMed] [Google Scholar]
  14. Narisawa T., Kono K., Yamaguchi T., Takahashi T. Cancer chemotherapy model using autochthonous large bowel cancer in rats. Gan. 1978 Jun;69(3):431–435. [PubMed] [Google Scholar]
  15. Narisawa T., Sato M., Tani M., Takahashi T. Chemoprevention of development of colonic adenomatosis and carcinomatosis with 5-fluorouracil and ftorafur on animal model. J Cancer Res Clin Oncol. 1980;97(3):223–232. doi: 10.1007/BF00405773. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Pozharisski K. M., Likhachev A. J., Klimashevski V. F., Shaposhnikov J. D. Experimental intestinal cancer research with special reference to human pathology. Adv Cancer Res. 1979;30:165–237. doi: 10.1016/s0065-230x(08)60897-0. [DOI] [PubMed] [Google Scholar]
  17. Sych F., Habs M., Schmähl D. Chemotherapy studies in autochthonous rat tumors intestinal cancer. Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1978 Aug 24;92(1):105–117. doi: 10.1007/BF00284097. [DOI] [PubMed] [Google Scholar]

Articles from Journal of the Royal Society of Medicine are provided here courtesy of Royal Society of Medicine Press

RESOURCES