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. 1984 May 5;288(6427):1327–1329. doi: 10.1136/bmj.288.6427.1327

Prenatal diagnosis of homozygous alpha thalassaemia by direct DNA analysis of uncultured amniotic fluid cells.

V Chan, A Ghosh, T K Chan, V Wong, D Todd
PMCID: PMC1440955  PMID: 6324946

Abstract

Prenatal diagnosis of homozygous alpha thalassaemia was performed in eight successive patients at risk using DNA from uncultured amniotic fluid cells. The presence of alpha gene was determined by restriction endonuclease mapping and hybridisation with cloned alpha and beta globin probes. This method is reliable and may be performed at 16 weeks of gestation.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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