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. 1984 May 5;288(6427):1332–1334. doi: 10.1136/bmj.288.6427.1332

Erythrocytic cation transport receptor numbers and activity in pregnancies complicated by essential hypertension and pre-eclampsia.

J K Aronson, M P Moore, C W Redman, C Harper
PMCID: PMC1440967  PMID: 6424846

Abstract

Various functions of erythrocytic cation transport were studied in normotensive and hypertensive pregnancy (women with pre-eclampsia and essential hypertension). The results showed that in pregnancy there is an increase in the number of erythrocytic glycoside binding sites accompanied by a proportional increase in the active inward transport of rubidium (used as a substitute for potassium). There was no evidence of an effect of pregnancy on intraerythrocytic sodium concentrations. These changes were apparently entirely attributable to pregnancy and not affected by pre-eclampsia or essential hypertension. It is suggested that these alterations indicate an adaptive increase in sodium pump numbers and activity secondary to a tendency for the intraerythrocytic sodium concentration to rise during pregnancy and compensating for that tendency.

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Selected References

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  1. Aronson J. K., Grahame-Smith D. G., Hallis K. F., Hibble A., Wigley F. Monitoring digoxin therapy: I. Plasma concentrations and an in vitro assay of tissue response. Br J Clin Pharmacol. 1977 Apr;4(2):213–221. doi: 10.1111/j.1365-2125.1977.tb00697.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Aronson J. K., Moore M. P., Redman C. W., Harper C. Sodium-lithium countertransport in erythrocytes of pregnant women. N Engl J Med. 1982 Dec 23;307(26):1645–1646. doi: 10.1056/NEJM198212233072615. [DOI] [PubMed] [Google Scholar]
  3. Boardman L. J., Hume S. P., Lamb J. F., Polson J. Effect of growth in lithium on ouabain binding, Na-K-ATPase and Na and K transport in hela cells. J Physiol. 1975 Jan;244(3):677–682. doi: 10.1113/jphysiol.1975.sp010819. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Boardman L. J., Lamb J. F., McCall D. Uptake of ( 3 H)ouabain and Na pump turnover rates in cells cultured in ouabain. J Physiol. 1972 Sep;225(3):619–635. doi: 10.1113/jphysiol.1972.sp009960. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Cumberbatch M., Zareian K., Davidson C., Morgan D. B., Swaminathan R. The early and late effects of digoxin treatment on the sodium transport, sodium content and Na+K+- ATPase or erythrocytes. Br J Clin Pharmacol. 1981 Jun;11(6):565–570. doi: 10.1111/j.1365-2125.1981.tb01172.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Ford A. R., Aronson J. K., Grahame-Smith D. G., Carver J. G. Changes in cardiac glycoside receptor sites, 86rubidium uptake and intracellular sodium concentrations in the erythrocytes of patients receiving digoxin during the early phases of treatment of cardiac failure in regular rhythm and of atrial fibrillation. Br J Clin Pharmacol. 1979 Aug;8(2):125–134. doi: 10.1111/j.1365-2125.1979.tb05810.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Ford A. R., Aronson J. K., Grahame-Smith D. G., Carver J. G. The acute changes seen in cardiac glycoside receptor sites, 86rubidium uptake and intracellular sodium concentrations in the erythrocytes of patients during the early phases of digoxin therapy are not found during chronic therapy: pharmacological and therapeutic implications for chronic digoxin therapy. Br J Clin Pharmacol. 1979 Aug;8(2):135–142. doi: 10.1111/j.1365-2125.1979.tb05811.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Ford A. R., Aronson J. K., Grahame-Smith D. G., Rose J. A. The characteristics of the binding of 12-alpha-[3H]-digoxin to the membranes of intact human erythrocytes: relevance to digoxin therapy. Br J Clin Pharmacol. 1979 Aug;8(2):115–124. doi: 10.1111/j.1365-2125.1979.tb05809.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Forrester T. E., Alleyne G. A. Leucocyte electrolytes and sodium efflux rate constants in the hypertension of pre-eclampsia. Clin Sci (Lond) 1980 Dec;59 (Suppl 6):199s–201s. doi: 10.1042/cs059199s. [DOI] [PubMed] [Google Scholar]
  10. Kuhnert B. R., Kuhnert P. M., Murray B. A., Sokol R. J. Na/K- and Mg-ATPase activity in the placenta and in maternal and cord erythrocytes of pre-eclamptic patients. Am J Obstet Gynecol. 1977 Jan 1;127(1):56–60. doi: 10.1016/0002-9378(77)90314-3. [DOI] [PubMed] [Google Scholar]
  11. MacGillivray I., Campbell D. M. The relevance of hypertension and oedema in pregnancy. Clin Exp Hypertens. 1980;2(5):897–914. doi: 10.3109/10641968009037148. [DOI] [PubMed] [Google Scholar]
  12. Rubython J., Morgan D. B. The effect of pregnancy and pregnancy induced hypertension on active sodium transport in the erythrocyte. Clin Chim Acta. 1983 Jul 31;132(1):91–99. doi: 10.1016/0009-8981(83)90236-x. [DOI] [PubMed] [Google Scholar]
  13. Weissberg P. L., Weaver J., Woods K. L., West M. J., Beevers D. G. Pregnancy induced hypertension: evidence for increased cell membrane permeability to sodium. Br Med J (Clin Res Ed) 1983 Sep 10;287(6394):709–711. doi: 10.1136/bmj.287.6394.709. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Worley R. J., Hentschel W. M., Cormier C., Nutting S., Pead G., Zelenkov K., Smith J. B., Ash K. O., Williams R. R. Increased sodium-lithium countertransport in erythrocytes of pregnant women. N Engl J Med. 1982 Aug 12;307(7):412–416. doi: 10.1056/NEJM198208123070706. [DOI] [PubMed] [Google Scholar]

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