Skip to main content
British Medical Journal (Clinical Research Ed.) logoLink to British Medical Journal (Clinical Research Ed.)
. 1984 May 5;288(6427):1335–1338. doi: 10.1136/bmj.288.6427.1335

Late mortality after vagotomy and drainage for duodenal ulcer.

P C Watt, C C Patterson, T L Kennedy
PMCID: PMC1440976  PMID: 6424847

Abstract

Seven hundred and thirty five patients who underwent elective vagotomy and drainage procedures in one hospital during 1957-67 were followed up until 1 September 1982. At this time 281 were dead compared with an expected 184. This gives a ratio of observed to expected deaths of 1.53 (p less than 0.0001). The most important cause of increased mortality was lung cancer, which accounted for 33 of the excess deaths (observed to expected ratio 3.53). Gastric cancer yielded an observed to expected ratio of 3.3. Other causes of death that were significantly more common than expected were cerebrovascular accident, bronchopneumonia, and colorectal cancer. It is concluded that although gastric cancer occurs more commonly after vagotomy and drainage than in the general population, it is not as important a cause of death as diseases related to smoking.

Full text

PDF
1335

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Cameron H. M., McGoogan E. A prospective study of 1152 hospital autopsies: I. Inaccuracies in death certification. J Pathol. 1981 Apr;133(4):273–283. doi: 10.1002/path.1711330402. [DOI] [PubMed] [Google Scholar]
  2. Clark C. G., Ward M. W., McDonald A. M., Tovey F. I. The incidence of gastric stump cancer. World J Surg. 1983 Mar;7(2):236–240. doi: 10.1007/BF01656150. [DOI] [PubMed] [Google Scholar]
  3. Din N. A., Small W. P. Proceedings: Death after partial gastrectomy for peptic ulcer--a long-term study. Gut. 1974 Apr;15(4):335–335. [PMC free article] [PubMed] [Google Scholar]
  4. Doll R., Peto R. Mortality in relation to smoking: 20 years' observations on male British doctors. Br Med J. 1976 Dec 25;2(6051):1525–1536. doi: 10.1136/bmj.2.6051.1525. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Domellöf L., Reddy B. S., Weisburger J. H. Microflora and deconjugation of bile acids in alkaline reflux after partial gastrectomy. Am J Surg. 1980 Aug;140(2):291–295. doi: 10.1016/0002-9610(80)90024-0. [DOI] [PubMed] [Google Scholar]
  6. HELSINGEN N., HILLESTAD L. Cancer development in the gastric stump after partial gastrectomy for ulcer. Ann Surg. 1956 Feb;143(2):173–179. doi: 10.1097/00000658-195614320-00003. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. KRAUSE U. Late prognosis after partial gastrectomy for ulcer; a follow-up study of 361 patients operated upon from 1905 to 1933. Acta Chir Scand. 1958 Apr 15;114(5):341–354. [PubMed] [Google Scholar]
  8. LIAVAAG K. Cancer development in gastric stump after partial gastrectomy for peptic ulcer. Ann Surg. 1962 Jan;155:103–106. doi: 10.1097/00000658-196201000-00012. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Reddy B. S., Narasawa T., Weisburger J. H., Wynder E. L. Promoting effect of sodium deoxycholate on colon adenocarcinomas in germfree rats. J Natl Cancer Inst. 1976 Feb;56(2):441–442. doi: 10.1093/jnci/56.2.441. [DOI] [PubMed] [Google Scholar]
  10. Ross A. H., Smith M. A., Anderson J. R., Small W. P. Late mortality after surgery for peptic ulcer. N Engl J Med. 1982 Aug 26;307(9):519–522. doi: 10.1056/NEJM198208263070902. [DOI] [PubMed] [Google Scholar]
  11. Stalsberg H., Taksdal S. Stomach cancer following gastric surgery for benign conditions. Lancet. 1971 Nov 27;2(7735):1175–1177. doi: 10.1016/s0140-6736(71)90489-2. [DOI] [PubMed] [Google Scholar]
  12. Turnbull P. R., Smith A. H., Isbister W. H. Cholecystectomy and cancer of the large bowel. Br J Surg. 1981 Aug;68(8):551–553. doi: 10.1002/bjs.1800680810. [DOI] [PubMed] [Google Scholar]
  13. Viskum K. Longevity and causes of death of peptic ulcer patients. Dan Med Bull. 1976 Jun;23(3):136–143. [PubMed] [Google Scholar]
  14. Welvaart K., Warnsinck H. M. The incidence of carcinoma of the gastric remnant. J Surg Oncol. 1982 Oct;21(2):104–106. doi: 10.1002/jso.2930210208. [DOI] [PubMed] [Google Scholar]

Articles from British Medical Journal (Clinical research ed.) are provided here courtesy of BMJ Publishing Group

RESOURCES