Abstract
Two young patients with unimpaired renal and hepatic function were found to have developed metabolic acidosis after treatment for glaucoma and joint pain with a combination of salicylates and carbonic anhydrase inhibitors in normal doses. Carbonic anhydrase inhibitors appear to interact with salicylates to produce serious metabolic acidosis in patients without the predisposing factors generally considered to constitute risks. It is recommended that treatment combining salicylates and carbonic anhydrase inhibitors is either kept to a minimum or avoided.
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Selected References
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- Lastnick G. Metabolic acidosis secondary to acetazolamide therapy a possible hazardous side effect after prolonged use of acetazolamide in geriatric patients. A case report. Ariz Med. 1975 Jan;32(1):19–21. [PubMed] [Google Scholar]
- MAREN T. H., WADSWORTH B. C., YALE E. K., ALONSO L. G. Carbonic anhydrase inhibition. III. Effects of diamox on electrolyte metabolism. Bull Johns Hopkins Hosp. 1954 Dec;95(6):277–321. [PubMed] [Google Scholar]
- Maisey D. N., Brown R. D. Acetazolamide and symptomatic metabolic acidosis in mild renal failure. Br Med J (Clin Res Ed) 1981 Dec 5;283(6305):1527–1528. doi: 10.1136/bmj.283.6305.1527. [DOI] [PMC free article] [PubMed] [Google Scholar]
- O'Sullivan P. J., Crowley J. G., Muldowney F. P. A case of acetazolamide induced (Diamox) acidotic coma in polycystic renal disease. J Ir Med Assoc. 1967 Oct;60(364):382–384. [PubMed] [Google Scholar]
- SCHWARTZ R., FELLERS F. X., KNAPP J., YAFFE S. The renal response to administration of acetazolamide (diamox) during salicylate intoxication. Pediatrics. 1959 Jun;23(6):1103–1114. [PubMed] [Google Scholar]
- Siklos P., Henderson R. G. Severe acidosis from acetazolamide in a diabetic patient. Curr Med Res Opin. 1979;6(4):284–286. doi: 10.1185/03007997909109439. [DOI] [PubMed] [Google Scholar]