Skip to main content
NCBI home page
British Medical Journal (Clinical Research Ed.) logoLink to British Medical Journal (Clinical Research Ed.)
. 1984 Sep 15;289(6446):651–654. doi: 10.1136/bmj.289.6446.651

Combined oral and nasal beclomethasone diproprionate in children with atopic eczema: a randomised controlled trial.

R J Heddle, J F Soothill, C J Bulpitt, D J Atherton
PMCID: PMC1443090  PMID: 6434024

Abstract

In a double blind, placebo controlled, crossover trial in 26 children with severe atopic eczema those receiving four weeks' treatment with combined oral plus nasal beclomethasone diproprionate improved significantly more than those receiving placebo. No adverse effects were observed, but 24 hour urinary cortisol excretion was slightly reduced. This combination may provide effective treatment in refractory atopic eczema with relatively little of the danger associated with systemic administration of prednisolone and other traditional corticosteroids.

Full text

PDF
651

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bhan G. L., Gwynn C. M., Smith J. M. Growth and adrenal function of children on prolonged beclomethasone dipropionate treatment. Lancet. 1980 Jan 12;1(8159):96–97. doi: 10.1016/s0140-6736(80)90522-x. [DOI] [PubMed] [Google Scholar]
  2. Dollery C. T., Davies D. S., Conolly M. E. Differences in the metabolism of drugs depending upon their routes of administration. Ann N Y Acad Sci. 1971 Jul 6;179:108–114. doi: 10.1111/j.1749-6632.1971.tb46893.x. [DOI] [PubMed] [Google Scholar]
  3. Francis R. S. Adrenocortical function during high-dose beclomethasone aerosol therapy. Clin Allergy. 1984 Jan;14(1):49–53. doi: 10.1111/j.1365-2222.1984.tb02189.x. [DOI] [PubMed] [Google Scholar]
  4. Godfrey S., Balfour-Lynn L., Tooley M. A three- to five-year follow-up of the use of the aerosol steroid, beclomethasone dipropionate, in childhood asthma. J Allergy Clin Immunol. 1978 Dec;62(6):335–339. doi: 10.1016/0091-6749(78)90133-1. [DOI] [PubMed] [Google Scholar]
  5. Harris D. M., Martin L. E., Harrison C., Jack D. The effect of intra-nasal beclomethasone dipropionate on adrenal function. Clin Allergy. 1974 Sep;4(3):291–294. doi: 10.1111/j.1365-2222.1974.tb01387.x. [DOI] [PubMed] [Google Scholar]
  6. Harris D. M., Martin L. E., Harrison C., Jack D. The effect of oral and inhaled beclomethasone dipropionate on adrenal function. Clin Allergy. 1973 Sep;3(3):243–248. doi: 10.1111/j.1365-2222.1973.tb01329.x. [DOI] [PubMed] [Google Scholar]
  7. Harris D. M. Some properties of beclomethasone dipropionate and related steroids in man. Postgrad Med J. 1975;51 (Suppl 4):20–25. [PubMed] [Google Scholar]
  8. Jackson P. G., Lessof M. H., Baker R. W., Ferrett J., MacDonald D. M. Intestinal permeability in patients with eczema and food allergy. Lancet. 1981 Jun 13;1(8233):1285–1286. doi: 10.1016/s0140-6736(81)92459-4. [DOI] [PubMed] [Google Scholar]
  9. Kerrebijn K. F. Beclomethasone dipropionate in long-term treatment of asthma in children. J Pediatr. 1976 Nov;89(5):821–826. doi: 10.1016/s0022-3476(76)80816-5. [DOI] [PubMed] [Google Scholar]
  10. Kershnar H., Klein R., Waldman D., Berger W., Rachelefsky G., Katz R., Siegel S. Treatment of chronic childhood asthma with beclomethasone dipropionate aerosols: II. Effect on pituitary-adrenal function after substitution for oral corticosteroids. Pediatrics. 1978 Aug;62(2):189–197. [PubMed] [Google Scholar]
  11. Lovera J., Cooper D. M., Collins-Williams C., Levison H., Bailey J. D., Orange R. P. Clinical and physiological assessment of asthmatic children treated with beclomethasone dipropionate. J Allergy Clin Immunol. 1976 Feb;57(2):112–123. doi: 10.1016/0091-6749(76)90030-0. [DOI] [PubMed] [Google Scholar]
  12. Martin L. E., Tanner R. J., Clark T. J., Cochrane G. M. Absorption and metabolism of orally administered beclomethsone dipropionate. Clin Pharmacol Ther. 1974 Mar;15(3):267–275. doi: 10.1002/cpt1974153267. [DOI] [PubMed] [Google Scholar]
  13. Mygind N. Local effect of intranasal beclomethasone dipropionate aerosol in hay fever. Br Med J. 1973 Nov 24;4(5890):464–466. doi: 10.1136/bmj.4.5890.464. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Mygind N., Sørensen H., Pedersen C. B. The nasal mucosa during long-term treatment with beclomethasone dipropionate aerosol. A light-and scanning electron microscopic study of nasal polyps. Acta Otolaryngol. 1978 May-Jun;85(5-6):437–443. [PubMed] [Google Scholar]
  15. Paganelli R., Levinsky R. J., Brostoff J., Wraith D. G. Immune complexes containing food proteins in normal and atopic subjects after oral challenge and effect of sodium cromoglycate on antigen absorption. Lancet. 1979 Jun 16;1(8129):1270–1272. doi: 10.1016/s0140-6736(79)92230-x. [DOI] [PubMed] [Google Scholar]
  16. Ukabam S. O., Mann R. J., Cooper B. T. Small intestinal permeability to sugars in patients with atopic eczema. Br J Dermatol. 1984 Jun;110(6):649–652. doi: 10.1111/j.1365-2133.1984.tb04699.x. [DOI] [PubMed] [Google Scholar]
  17. Wyatt R., Waschek J., Weinberger M., Sherman B. Effects of inhaled beclomethasone dipropionate and alternate-day prednisone on pituitary-adrenal function in children with chronic asthma. N Engl J Med. 1978 Dec 21;299(25):1387–1392. doi: 10.1056/NEJM197812212992504. [DOI] [PubMed] [Google Scholar]

Articles from British Medical Journal (Clinical research ed.) are provided here courtesy of BMJ Publishing Group

RESOURCES