Abstract
Four men presented with unexplained lymphadenopathy. Three had a history of recurrent respiratory infections for several years, and two had lymph node or hepatic granulomas. None was noted to have symptoms of immunodeficiency at the time of presentation. In one patient routine direct immunofluorescence study failed to detect IgA, and immunological investigations were therefore conducted in the rest. In all patients the findings were similar and characterised by a severe deficiency of IgA. In the absence of a more serious cause selective IgA deficiency may be enough to explain "idiopathic" lymphadenopathy.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- French M. A., Harrison G. Serum IgG subclass concentrations in healthy adults: a study using monoclonal antisera. Clin Exp Immunol. 1984 May;56(2):473–475. [PMC free article] [PubMed] [Google Scholar]
- French M. A., Harrison G. Systemic antibody deficiency in patients without serum immunoglobulin deficiency or with selective IgA deficiency. Clin Exp Immunol. 1984 Apr;56(1):18–22. [PMC free article] [PubMed] [Google Scholar]
- Sharma O. P., James D. G. Hypogammaglobulinemia, depression of delayed-type hypersensitivity, and granuloma formation. Am Rev Respir Dis. 1971 Aug;104(2):228–231. doi: 10.1164/arrd.1971.104.2.228. [DOI] [PubMed] [Google Scholar]