Skip to main content
PMC home page
British Medical Journal (Clinical Research Ed.) logoLink to British Medical Journal (Clinical Research Ed.)
. 1984 Oct 27;289(6452):1103–1106. doi: 10.1136/bmj.289.6452.1103

Calcium supplementation and postmenopausal bone loss.

L Nilas, C Christiansen, P Rødbro
PMCID: PMC1443268  PMID: 6435793

Abstract

A series of 103 early postmenopausal women completed a questionnaire about their dietary calcium intake and were then divided into three groups: those with an intake below 550 mg/day, those with an intake between 550 and 1150 mg/day, and those with an intake above 1150 mg/day. Thereafter they were given a daily supplement of 500 mg calcium for two years and had their bone mineral content measured every three months. Any changes found were taken as an estimate of bone calcium balance. All three groups showed a similar fall in bone mineral content over the two years, indicating that a calcium intake of 1000-2000 g daily is ineffective in preventing bone loss in the early menopause.

Full text

PDF
1103

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Christensen M. S. A sensitive radioimmunoassay of parathyroid hormone in human serum using a specific extraction procedure. Scand J Clin Lab Invest. 1976 Jul;36(4):313–322. doi: 10.1080/00365517609055266. [DOI] [PubMed] [Google Scholar]
  2. Christensen M. S., Hagen C., Christiansen C., Transbøl I. Dose-response evaluation of cyclic estrogen/gestagen in postmenopausal women: placebo-controlled trial of its gynecologic and metabolic actions. Am J Obstet Gynecol. 1982 Dec 15;144(8):873–879. doi: 10.1016/0002-9378(82)90176-4. [DOI] [PubMed] [Google Scholar]
  3. Christiansen C., Christensen M. S., McNair P., Hagen C., Stocklund K. E., Transbøl I. Prevention of early postmenopausal bone loss: controlled 2-year study in 315 normal females. Eur J Clin Invest. 1980 Aug;10(4):273–279. doi: 10.1111/j.1365-2362.1980.tb00033.x. [DOI] [PubMed] [Google Scholar]
  4. Christiansen C., Christensen M. S., Rødbro P., Hagen C., Transbøl I. Effect of 1,25-dihydroxy-vitamin D3 in itself or combined with hormone treatment in preventing postmenopausal osteoporosis. Eur J Clin Invest. 1981 Aug;11(4):305–309. doi: 10.1111/j.1365-2362.1981.tb02121.x. [DOI] [PubMed] [Google Scholar]
  5. Christiansen C., Rödbro P. Long-term reproducibility of bone mineral content measurements. Scand J Clin Lab Invest. 1977 Jun;37(4):321–323. doi: 10.3109/00365517709092636. [DOI] [PubMed] [Google Scholar]
  6. Heaney R. P., Recker R. R., Saville P. D. Calcium balance and calcium requirements in middle-aged women. Am J Clin Nutr. 1977 Oct;30(10):1603–1611. doi: 10.1093/ajcn/30.10.1603. [DOI] [PubMed] [Google Scholar]
  7. Heaney R. P., Recker R. R., Saville P. D. Menopausal changes in calcium balance performance. J Lab Clin Med. 1978 Dec;92(6):953–963. [PubMed] [Google Scholar]
  8. Horsman A., Gallagher J. C., Simpson M., Nordin B. E. Prospective trial of oestrogen and calcium in postmenopausal women. Br Med J. 1977 Sep 24;2(6090):789–792. doi: 10.1136/bmj.2.6090.789. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Jensen G. F., Christiansen C., Boesen J., Hegedüs V., Transbøl I. Epidemiology of postmenopausal spinal and long bone fractures. A unifying approach to postmenopausal osteoporosis. Clin Orthop Relat Res. 1982 Jun;(166):75–81. [PubMed] [Google Scholar]
  10. Jensen J. S. Trochanteric fractures. An epidemiological, clinical and biomechanical study. Acta Orthop Scand Suppl. 1981;188:1–100. doi: 10.3109/ort.1981.52.suppl-188.01. [DOI] [PubMed] [Google Scholar]
  11. Marshall D. H., Horsman A., Nordin B. E. The prevention and management of post-menopausal osteoporosis. Acta Obstet Gynecol Scand Suppl. 1977;65:49–56. doi: 10.3109/00016347709156341. [DOI] [PubMed] [Google Scholar]
  12. Nachtigall L. E., Nachtigall R. H., Nachtigall R. D., Beckman E. M. Estrogen replacement therapy I: a 10-year prospective study in the relationship to osteoporosis. Obstet Gynecol. 1979 Mar;53(3):277–281. [PubMed] [Google Scholar]
  13. Recker R. R., Saville P. D., Heaney R. P. Effect of estrogens and calcium carbonate on bone loss in postmenopausal women. Ann Intern Med. 1977 Dec;87(6):649–655. doi: 10.7326/0003-4819-87-6-649. [DOI] [PubMed] [Google Scholar]
  14. Riggs B. L., Seeman E., Hodgson S. F., Taves D. R., O'Fallon W. M. Effect of the fluoride/calcium regimen on vertebral fracture occurrence in postmenopausal osteoporosis. Comparison with conventional therapy. N Engl J Med. 1982 Feb 25;306(8):446–450. doi: 10.1056/NEJM198202253060802. [DOI] [PubMed] [Google Scholar]
  15. Weiss N. S., Ure C. L., Ballard J. H., Williams A. R., Daling J. R. Decreased risk of fractures of the hip and lower forearm with postmenopausal use of estrogen. N Engl J Med. 1980 Nov 20;303(21):1195–1198. doi: 10.1056/NEJM198011203032102. [DOI] [PubMed] [Google Scholar]

Articles from British Medical Journal (Clinical research ed.) are provided here courtesy of BMJ Publishing Group

RESOURCES