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. 1984 Oct 6;289(6449):896–898. doi: 10.1136/bmj.289.6449.896

Cervical smear histories of 500 women with invasive cervical cancer in Yorkshire.

M E Paterson, K R Peel, C A Joslin
PMCID: PMC1443405  PMID: 6434133

Abstract

The smear histories of 312 women with cancer of the cervix have been determined. Eighty nine women had had at least one negative smear reported in the 10 years before a diagnosis of cancer and 14 had had more than one negative smear. Fifty six of the 89 women had had a negative smear in the three years preceding the diagnosis of cancer. The highest number of negative smears (61) reported was among the 115 women aged under 45. Fifty eight slides reported as negative were submitted to independent review; 13 were subsequently reported as negative, 11 as unsatisfactory, and 34 as abnormal. These findings may in part explain why in this region there has been a disappointing reduction in the incidence of clinically invasive cervix cancer, and our findings may also apply elsewhere. Nevertheless, the confirmed negative smears chiefly occurred within three years of clinical cancer, particularly in the younger women, and this finding suggests that these women may have a short preinvasive phase.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Berkeley A. S., LiVolsi V. A., Schwartz P. E. Advanced squamous cell carcinoma of the cervix with recent normal Papanicolaou tests. Lancet. 1980 Aug 16;2(8190):375–376. doi: 10.1016/s0140-6736(80)90378-5. [DOI] [PubMed] [Google Scholar]
  2. Boyes D. A. The value of a Pap smear program and suggestions for its implementation. Cancer. 1981 Jul 15;48(2 Suppl):613–621. doi: 10.1002/1097-0142(19810715)48:1+<613::aid-cncr2820481328>3.0.co;2-z. [DOI] [PubMed] [Google Scholar]
  3. Clarke E. A., Anderson T. W. Implications of cervical dysplasia. Lancet. 1980 Jun 28;1(8183):1420–1420. doi: 10.1016/s0140-6736(80)92688-4. [DOI] [PubMed] [Google Scholar]
  4. Davy M., Bentzen H., Jahren R. Simple hysterectomy in the presence of invasive cervical cancer. Acta Obstet Gynecol Scand. 1977;56(2):105–108. doi: 10.3109/00016347709158350. [DOI] [PubMed] [Google Scholar]
  5. Dunn J. E., Jr, Schweitzer V. The relationship of cervical cytology to the incidence of invasive cervical cancer and mortality in Alameda County, California, 1960 to 1974. Am J Obstet Gynecol. 1981 Apr 15;139(8):868–876. doi: 10.1016/0002-9378(81)90951-0. [DOI] [PubMed] [Google Scholar]
  6. Green G. H. Cervical cancer and cytology screening in New Zealand. Br J Obstet Gynaecol. 1978 Dec;85(12):881–886. doi: 10.1111/j.1471-0528.1978.tb15848.x. [DOI] [PubMed] [Google Scholar]
  7. Hakama M., Räsänen-Virtanen U. Effect of a mass screening program on the risk of cervical cancer. Am J Epidemiol. 1976 May;103(5):512–517. doi: 10.1093/oxfordjournals.aje.a112253. [DOI] [PubMed] [Google Scholar]
  8. Holman C. D., McCartney A. J., Hyde K. L., Armstrong B. K. Cervical cytology histories of 100 women with invasive carcinoma of the cervix. Med J Aust. 1981 Nov 28;2(11):597–598. doi: 10.5694/j.1326-5377.1981.tb113010.x. [DOI] [PubMed] [Google Scholar]
  9. Husain O. A., Butler E. B., Evans D. M., Macgregor J. E., Yule R. Quality control in cervical cytology. J Clin Pathol. 1974 Dec;27(12):935–944. doi: 10.1136/jcp.27.12.935. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Johannesson G., Geirsson G., Day N. The effect of mass screening in Iceland, 1965-74, on the incidence and mortality of cervical carcinoma. Int J Cancer. 1978 Apr 15;21(4):418–425. doi: 10.1002/ijc.2910210404. [DOI] [PubMed] [Google Scholar]
  11. Knox E. G. Ages and frequencies for cervical cancer screening. Br J Cancer. 1976 Oct;34(4):444–452. doi: 10.1038/bjc.1976.190. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Macgregor J. E., Teper S. Mortality from carcinoma of cervix uteri in Britain. Lancet. 1978 Oct 7;2(8093):774–776. doi: 10.1016/s0140-6736(78)92658-2. [DOI] [PubMed] [Google Scholar]
  13. Parkin D. M., Leach K., Cobb P., Clayden A. D. Cervical cytology screening in two Yorkshire areas: results of testing. Public Health. 1982 Jan;96(1):3–14. doi: 10.1016/s0033-3506(82)80023-1. [DOI] [PubMed] [Google Scholar]
  14. Prendiville W., Guillebeaud J., Bamford P., Beilby J., Steele S. J. Carcinoma of cervix with recent normal Papanicolaou tests. Lancet. 1980 Oct 18;2(8199):853–854. doi: 10.1016/s0140-6736(80)90191-9. [DOI] [PubMed] [Google Scholar]
  15. Richart R. M., Barron B. A. A follow-up study of patients with cervical dysplasia. Am J Obstet Gynecol. 1969 Oct 1;105(3):386–393. doi: 10.1016/0002-9378(69)90268-3. [DOI] [PubMed] [Google Scholar]
  16. Walker E. M., Hare M. J., Cooper P. A retrospective review of cervical cytology in women developing invasive squamous cell carcinoma. Br J Obstet Gynaecol. 1983 Nov;90(11):1087–1091. doi: 10.1111/j.1471-0528.1983.tb06449.x. [DOI] [PubMed] [Google Scholar]

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