Abstract
In an inpatient survey the medication records of 2004 mothers both breast and bottle feeding were examined and the drugs taken in the early postnatal period recorded. No notable differences existed between the types of drugs prescribed for breast feeding and bottle feeding mothers. Iron, vitamins, and mild analgesics were taken routinely by the population, and antibiotics, laxatives, and hypnotics were frequently prescribed. A wide range of other drugs and preparations were taken or used. Although data were available for some of the drugs, there were many whose concentrations in breast milk and potential risk to the suckling infant were unknown. Data are urgently required on hypnotics, narcotic analgesics, antiemetics, antihistaminics, and some antimicrobial agents with respect to their concentrations in breast milk and their safety for the suckling infant.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Bailey D. N., Weibert R. T., Naylor A. J., Shaw R. F. A study of salicylate and caffeine excretion in the breast milk of two nursing mothers. J Anal Toxicol. 1982 Mar-Apr;6(2):64–68. doi: 10.1093/jat/6.2.64. [DOI] [PubMed] [Google Scholar]
- Berlin C. M., Jr, Yaffe S. J., Ragni M. Disposition of acetaminophen in milk, saliva, and plasma of lactating women. Pediatr Pharmacol (New York) 1980;1(2):135–141. [PubMed] [Google Scholar]
- Bitzén P. O., Gustafsson B., Jostell K. G., Melander A., Wåhlin-Boll E. Excretion of paracetamol in human breast milk. Eur J Clin Pharmacol. 1981;20(2):123–125. doi: 10.1007/BF00607148. [DOI] [PubMed] [Google Scholar]
- Coles E. C., Valman H. B. Letter: Breast-feeding in Harrow. Lancet. 1976 Sep 11;2(7985):583–583. doi: 10.1016/s0140-6736(76)91842-0. [DOI] [PubMed] [Google Scholar]
- Findlay J. W., DeAngelis R. L., Kearney M. F., Welch R. M., Findlay J. M. Analgesic drugs in breast milk and plasma. Clin Pharmacol Ther. 1981 May;29(5):625–633. doi: 10.1038/clpt.1981.87. [DOI] [PubMed] [Google Scholar]
- Herbst A. L., Scully R. E. Adenocarcinoma of the vagina in adolescence. A report of 7 cases including 6 clear-cell carcinomas (so-called mesonephromas). Cancer. 1970 Apr;25(4):745–757. doi: 10.1002/1097-0142(197004)25:4<745::aid-cncr2820250402>3.0.co;2-2. [DOI] [PubMed] [Google Scholar]
- Knowles J. A. Breast milk: a source of more than nutrition for the neonate. Clin Toxicol. 1974;7(1):69–82. doi: 10.3109/15563657408987978. [DOI] [PubMed] [Google Scholar]
- Saxena B. N., Shrimanker K., Grudzinskas J. G. Levels of contraceptive seroids in breast milk and plasma of lactating women. Contraception. 1977 Dec;16(6):605–613. doi: 10.1016/0010-7824(77)90061-0. [DOI] [PubMed] [Google Scholar]
- Taitz L. S. Breast feeding trends in Sheffield 1976-82. Br Med J (Clin Res Ed) 1983 Sep 3;287(6393):648–648. doi: 10.1136/bmj.287.6393.648. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Thaler M. M. Jaundice in the newborn. Algorithmic diagnosis of conjugated and unconjugated hyperbilirubinemia. JAMA. 1977 Jan 3;237(1):58–62. doi: 10.1001/jama.237.1.58. [DOI] [PubMed] [Google Scholar]
- Traeger A., Peiker G. Excretion of nalidixic acid via mother's milk. Arch Toxicol Suppl. 1980;4:388–390. doi: 10.1007/978-3-642-67729-8_85. [DOI] [PubMed] [Google Scholar]
- Wilson J. T., Brown R. D., Cherek D. R., Dailey J. W., Hilman B., Jobe P. C., Manno B. R., Manno J. E., Redetzki H. M., Stewart J. J. Drug excretion in human breast milk: principles, pharmacokinetics and projected consequences. Clin Pharmacokinet. 1980 Jan-Feb;5(1):1–66. doi: 10.2165/00003088-198005010-00001. [DOI] [PubMed] [Google Scholar]