Skip to main content
British Medical Journal (Clinical Research Ed.) logoLink to British Medical Journal (Clinical Research Ed.)
. 1984 Jan 28;288(6413):267–268. doi: 10.1136/bmj.288.6413.267

Avascular necrosis of bone caused by combination chemotherapy without corticosteroids.

P G Harper, C Trask, R L Souhami
PMCID: PMC1444026  PMID: 6198019

Abstract

Avascular necrosis of bone is sometimes a complication of cancer chemotherapy that includes corticosteroids but generally occurs at a single site. A patient with testicular teratoma who received chemotherapy that did not include steroids developed avascular necrosis of the left femoral head, left scaphoid, and both medial femoral condyles. Symptoms were relieved with anti-inflammatory drugs and physiotherapy. This case indicates that avascular necrosis may be caused by cancer chemotherapy that does not include steroids.

Full text

PDF

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Harrington K. D., Murray W. R., Kountz S. L., Belzer F. O. Avascular necrosis of bone after renal transplantation. J Bone Joint Surg Am. 1971 Mar;53(2):203–215. [PubMed] [Google Scholar]
  2. Ihde D. C., DeVita V. T. Osteonecrosis of the femoral head in patients with lymphoma treated with intermittent combination chemotherapy (including corticosteroids). Cancer. 1975 Nov;36(5):1585–1588. doi: 10.1002/1097-0142(197511)36:5<1585::aid-cncr2820360508>3.0.co;2-d. [DOI] [PubMed] [Google Scholar]
  3. Obrist R., Hartmann D., Obrecht J. P. Osteonecrosis after chemotherapy. Lancet. 1978 Jun 17;1(8077):1316–1316. doi: 10.1016/s0140-6736(78)91306-5. [DOI] [PubMed] [Google Scholar]
  4. Thorne J. C., Evans W. K., Alison R. E., Fournasier V. Avascular necrosis of bone complicating treatment of malignant lymphoma. Am J Med. 1981 Nov;71(5):751–758. doi: 10.1016/0002-9343(81)90354-5. [DOI] [PubMed] [Google Scholar]
  5. Timothy A. R., Tucker A. K., Park W. M., Cannell L. B. Osteonecrosis in Hodgkin's disease. Br J Radiol. 1978 May;51(605):328–332. doi: 10.1259/0007-1285-51-605-328. [DOI] [PubMed] [Google Scholar]

Articles from British Medical Journal (Clinical research ed.) are provided here courtesy of BMJ Publishing Group

RESOURCES