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British Medical Journal (Clinical Research Ed.) logoLink to British Medical Journal (Clinical Research Ed.)
. 1984 Jan 7;288(6410):7–9. doi: 10.1136/bmj.288.6410.7

Interpretation of single progesterone measurement in diagnosis of anovulation and defective luteal phase: observations on analysis of the normal range.

N C Wathen, L Perry, R J Lilford, T Chard
PMCID: PMC1444184  PMID: 6418326

Abstract

Single serum progesterone determinations were made in 79 apparently normal women with a regular menstrual cycle. A normal range (40 subjects) was derived from the concentrations in the follicular phase and used to define an "anovular" range for luteal phase values (nine out of 39 subjects). The remaining luteal phase values were used to construct an "ovular" range for the luteal phase and, within this range, to define a group of values (less than the 20th centile) which could be described as a "defective luteal phase." The cut off limits between ovular and anovular and between normal and defective luteal phases were respectively two and four times the follicular phase median. It is proposed that the numerical findings of this study may be used as a rule of thumb for defining normality and abnormality from a single serum progesterone determination.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Abdulla U., Diver M. J., Hipkin L. J., Davis J. C. Plasma progesterone levels as an index of ovulation. Br J Obstet Gynaecol. 1983 Jun;90(6):543–548. doi: 10.1111/j.1471-0528.1983.tb08965.x. [DOI] [PubMed] [Google Scholar]
  2. Abraham G. E., Maroulis G. B., Marshall J. R. Evaluation of ovulation and corpus luteum function using measurements of plasma progesterone. Obstet Gynecol. 1974 Oct;44(4):522–525. [PubMed] [Google Scholar]
  3. Abraham G. E., Odell W. D., Swerdloff R. S., Hopper K. Simultaneous radioimmunoassay of plasma FSH, LH, progesterone, 17-hydroxyprogesterone, and estradiol-17 beta during the menstrual cycle. J Clin Endocrinol Metab. 1972 Feb;34(2):312–318. doi: 10.1210/jcem-34-2-312. [DOI] [PubMed] [Google Scholar]
  4. Coutts J. R., Adam A. H., Fleming R. The deficient luteal phase may represent an anovulatory cycle. Clin Endocrinol (Oxf) 1982 Oct;17(4):389–394. doi: 10.1111/j.1365-2265.1982.tb01604.x. [DOI] [PubMed] [Google Scholar]
  5. Hull M. G., Savage P. E., Bromham D. R., Ismail A. A., Morris A. F. The value of a single serum progesterone measurement in the midluteal phase as a criterion of a potentially fertile cycle ("ovulation") derived form treated and untreated conception cycles. Fertil Steril. 1982 Mar;37(3):355–360. doi: 10.1016/s0015-0282(16)46095-4. [DOI] [PubMed] [Google Scholar]
  6. Israel R., Mishell D. R., Jr, Stone S. C., Thorneycroft I. H., Moyer D. L. Single luteal phase serum progesterone assay as an indicator of ovulation. Am J Obstet Gynecol. 1972 Apr 15;112(8):1043–1046. doi: 10.1016/0002-9378(72)90178-0. [DOI] [PubMed] [Google Scholar]
  7. Jones G. S. Luteal phase insufficiency. Clin Obstet Gynecol. 1973 Sep;16(3):255–273. doi: 10.1097/00003081-197309000-00016. [DOI] [PubMed] [Google Scholar]
  8. Jones G. S. The luteal phase defect. Fertil Steril. 1976 Apr;27(4):351–356. doi: 10.1016/s0015-0282(16)41769-3. [DOI] [PubMed] [Google Scholar]
  9. Ross G. T., Cargille C. M., Lipsett M. B., Rayford P. L., Marshall J. R., Strott C. A., Rodbard D. Pituitary and gonadal hormones in women during spontaneous and induced ovulatory cycles. Recent Prog Horm Res. 1970;26:1–62. doi: 10.1016/b978-0-12-571126-5.50005-4. [DOI] [PubMed] [Google Scholar]
  10. Schmidt-Gollwitzer M., Eiletz J., Sackmann U., Nevinny-Stickel J. Detection of ovulation by a radioreceptor assay for human luteinizing hormone. J Clin Endocrinol Metab. 1978 Jun;46(6):902–906. doi: 10.1210/jcem-46-6-902. [DOI] [PubMed] [Google Scholar]
  11. Shaaban M. M., Klopper A. Plasma oestradiol and progesterone concentration in the normal menstrual cycle. J Obstet Gynaecol Br Commonw. 1973 Sep;80(9):776–782. doi: 10.1111/j.1471-0528.1973.tb11218.x. [DOI] [PubMed] [Google Scholar]
  12. Tulchinsky D., Hobel C. J. Plasma human chorionic gonadotropin, estrone, estradiol, estriol, progesterone, and 17 alpha-hydroxyprogesterone in human pregnancy. 3. Early normal pregnancy. Am J Obstet Gynecol. 1973 Dec 1;117(7):884–893. doi: 10.1016/0002-9378(73)90057-4. [DOI] [PubMed] [Google Scholar]

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