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. 1984 Mar 10;288(6419):745–748. doi: 10.1136/bmj.288.6419.745

Effect of aspirin in "aspirin sensitive" patients.

S I Asad, D M Kemeny, L J Youlten, A W Frankland, M H Lessof
PMCID: PMC1444623  PMID: 6423060

Abstract

Eighteen patients with a history of urticaria or asthma, or both, induced by aspirin were studied before and after provocation of symptoms with aspirin. The plasma prostaglandin F2 alpha concentration, which was characteristically raised before challenge, fell significantly at the time of adverse reactions. Repeated administration of aspirin up to a dose of 650 mg daily induced tolerance in most of the patients, and several developed bronchodilator responses to aspirin. Although median total IgE concentrations may be raised in patients with aspirin sensitivity, it appears likely that pharmacological rather than immunological mechanisms are chiefly responsible for the phenomena of aspirin sensitivity and desensitisation.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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