Skip to main content
NCBI home page
British Medical Journal (Clinical Research Ed.) logoLink to British Medical Journal (Clinical Research Ed.)
. 1984 Mar 10;288(6419):754–755. doi: 10.1136/bmj.288.6419.754

Reduced serum free thyroxine concentration in postmenopausal women receiving oestrogen treatment.

H I Abdalla, D M Hart, G H Beastall
PMCID: PMC1444662  PMID: 6423063

Abstract

Thyroid hormone state was assessed in a group of postmenopausal women who had received long term treatment with oestrogen. Serum concentrations of total thyroxine, triiodothyronine, and thyroxine binding globulin were raised compared with those in a control group given placebo; serum concentrations of thyroid stimulating hormone did not differ between the groups. Oestrogen treatment resulted in a significant decrease in the serum free thyroxine concentration and in the ratio of thyroxine to thyroxine binding globulin, which supports the view that oestrogen is the causative factor of the physiological reduction in free thyroid hormone during pregnancy.

Full text

PDF
754

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Aitken J. M., Hart D. M., Lindsay R. Oestrogen replacement therapy for prevention of osteoporosis after oophorectomy. Br Med J. 1973 Sep 8;3(5879):515–518. doi: 10.1136/bmj.3.5879.515. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Boss A. M., Kingstone D. Further observations on serum free thyroxine concentrations during pregnancy. Br Med J (Clin Res Ed) 1981 Aug 29;283(6291):584–584. doi: 10.1136/bmj.283.6291.584. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. DOWLING J. T., FREINKEL N., INGBAR S. H. Effect of diethylstilbestrol on the binding of thyroxine in serum. J Clin Endocrinol Metab. 1956 Nov;16(11):1491–1506. doi: 10.1210/jcem-16-11-1491. [DOI] [PubMed] [Google Scholar]
  4. Franklyn J. A., Sheppard M. C., Ramsden D. B. Serum free thyroxine and free triiodothyronine concentrations in pregnancy. Br Med J (Clin Res Ed) 1983 Aug 6;287(6389):394–394. doi: 10.1136/bmj.287.6389.394. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Helenius T., Liewendahl K. Improved dialysis method for free thyroxin in serum compared with five commercial radioimmunoassays in nonthyroidal illness and subjects with abnormal concentrations of thyroxin-binding globulin. Clin Chem. 1983 May;29(5):816–822. [PubMed] [Google Scholar]
  6. Hopton M. R., Ashwell K., Scott I. V., Harrop J. S. Serum free thyroxine concentration and free thyroid hormone indices in normal pregnancy. Clin Endocrinol (Oxf) 1983 Apr;18(4):431–437. doi: 10.1111/j.1365-2265.1983.tb00589.x. [DOI] [PubMed] [Google Scholar]
  7. Kurtz A., Dwyer K., Ekins R. Serum free thyroxine in pregnancy. Br Med J. 1979 Sep 1;2(6189):550–551. doi: 10.1136/bmj.2.6189.550-c. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Lecureuil M., Crouzat-Reynes G., Besnard J. C., Choffel C. Correlation of free thyroxine index and thyroxine: thyroxine-binding globulin ratio with the free thyroxine concentration as measured by the thyroxine and thyroxine-binding globulin radioimmunoassays. Clin Chim Acta. 1978 Aug 1;87(3):373–381. doi: 10.1016/0009-8981(78)90181-x. [DOI] [PubMed] [Google Scholar]
  9. Rootwelt K., Solberg H. E. Free thyroxine, thyroxine/TBG ratio and other in vitro tests of thyroid function evaluated by discriminant analysis. Scand J Clin Lab Invest. 1981 Sep;41(5):483–491. doi: 10.3109/00365518109090487. [DOI] [PubMed] [Google Scholar]
  10. Wellby M. L., Guthrie L., Reilly C. P. Evaluation of a new free-thyroxin assay. Clin Chem. 1981 Dec;27(12):2022–2024. [PubMed] [Google Scholar]
  11. Zaninovich A. A., Boado R., Ulloa E., Bromage N. R., Matty A. J. Inhibition of thyroidal iodine release by oestrogens in euthyroid subjects. Acta Endocrinol (Copenh) 1982 Mar;99(3):386–392. doi: 10.1530/acta.0.0990386. [DOI] [PubMed] [Google Scholar]

Articles from British Medical Journal (Clinical research ed.) are provided here courtesy of BMJ Publishing Group

RESOURCES