Skip to main content
NCBI home page
Immunology logoLink to Immunology
. 1976 Apr;30(4):475–477.

Lymphocyte nucleoli activation as a marker of autoimmune disorder development. I. Observation in NZB mice.

L Korcáková, J Rovenský, J Pekárek, V Haskova
PMCID: PMC1445016  PMID: 1270084

Abstract

An increased number of lymphocytes with nucleoli synthesizing RNA was found in blood and lymph nodes of aged NZB mice who developed an autoimmune disease. This was not observed in young NZB mice and in 40NX mice where no immune disorders were noted.

Full text

PDF
475

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Abe T., Hara M., Yamasaki K., Homma M. Cell-mediated immune response in systemic lupus erythematosus. In vitro cellular response to native DNA by macrophage inhibitory test. Arthritis Rheum. 1973 Sep-Oct;16(5):688–694. doi: 10.1002/art.1780160514. [DOI] [PubMed] [Google Scholar]
  2. Baum J. Increased 7S antibody response to sheep erythrocytes in the 2-month-old NZB mouse. Clin Exp Immunol. 1969 Sep;5(3):251–263. [PMC free article] [PubMed] [Google Scholar]
  3. Blankwater M. J., Levert L. A., Hijmans W. Age-related decline in the antibody response to E. coli lipopolysaccharide in New Zealand Black mice. Immunology. 1975 May;28(5):847–854. [PMC free article] [PubMed] [Google Scholar]
  4. Cantor H., Asofsky R., Talal N. Synergy among lymphoid cells mediating the graft-versus-host response. I. Synergy in graft-versus-host reactions produced by cells from NZB-Bl mice. J Exp Med. 1970 Feb;131(2):223–234. doi: 10.1084/jem.131.2.223. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Cerottini J. C., Lambert P. H., Dixon F. J. Comparison of the immune responsiveness of NZB and NZB X NZW F1 hybrid mice with that of other strains of mice. J Exp Med. 1969 Nov 1;130(5):1093–1105. doi: 10.1084/jem.130.5.1093. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Dormont J., Sobel A., Galanaud P., Boelaert J., Mery J. P., Richet G. Exploration de l'immunité cellulaire au cours du lupus érythémateux disséminé. J Urol Nephrol (Paris) 1972 Dec;78(12):980–987. [PubMed] [Google Scholar]
  7. Gerber N. L., Hardin J. A., Chused T. M., Steinberg A. D. Loss with age in NZB-W mice of thymic suppressor cells in the graft-vs-host reaction. J Immunol. 1974 Nov;113(5):1618–1625. [PubMed] [Google Scholar]
  8. Morton J. I., Siegel B. V. Response of NZB mice to foreign antigen and development of autoimmune disease. J Reticuloendothel Soc. 1969 Feb;6(1):78–93. [PubMed] [Google Scholar]
  9. Moulias R., Goust J. M., Reinert P., Devillechabrolle A., Muller Berat C. N., Hereman C., Godeau P. Le test de migration en présence d'ADN des leucocytes au cours du lupus érythémateux disséminé. Nouv Presse Med. 1972 May 20;1(21):1403–1407. [PubMed] [Google Scholar]
  10. Nekvasil M., Pekárek J. Activation of the peripheral lymphocytes in the course of the immune response to transplanted SV40-transformed tumour cells in hamsters. Immunology. 1974 Jul;27(1):159–161. [PMC free article] [PubMed] [Google Scholar]
  11. Pekárek J., Svejcar J., Zitnan D., Rovensky J., Cebecauer L. Spontaneous delayed hypersensitivity to DNA in NZB mice. Immunology. 1974 Aug;27(2):241–244. [PMC free article] [PubMed] [Google Scholar]
  12. Pekárek J., Vepreková A., Doutlík S. Activation of peripheral lymphocytes in the course of experimental allergic encephalomyelitis in the guinea-pig. Z Immunitatsforsch Exp Klin Immunol. 1972 Mar;143(2):139–146. [PubMed] [Google Scholar]
  13. Rodey G. E., Good R. A., Yunis E. J. Progressive loss in vitro of cellular immunity with ageing in strains of mice susceptible to autoimmune disease. Clin Exp Immunol. 1971 Sep;9(3):305–311. [PMC free article] [PubMed] [Google Scholar]
  14. Svejcar J., Rovenský J., Pekárek J., Zitńan D., Cebecauer L. Delayed hypersensitivity to DNA in systemic lupus erythematosus and related diseases. Z Immunitatsforsch Exp Klin Immunol. 1974 Dec;148(3):244–253. [PubMed] [Google Scholar]
  15. Talal N. Immunologic and viral factors in the pathogenesis of systemic lupus erythematosus. Arthritis Rheum. 1970 Nov-Dec;13(6):887–894. doi: 10.1002/art.1780130620. [DOI] [PubMed] [Google Scholar]

Articles from Immunology are provided here courtesy of British Society for Immunology

RESOURCES