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. 1976 Jun;30(6):907–914.

Development of B-lymphocyte colony-forming cells in foetal mouse tissues.

G R Johnson, D Metcalf, J W Wilson
PMCID: PMC1445078  PMID: 1088416

Abstract

In CBA and (CBA X C57B1)F1 mice, cells forming B-lymphocyte colonies in agar culture were first detected in the 17-day foetal liver and the following day in the spleen, bone marrow and peripheral blood. Colony-forming cells were not detected in the yolk sac or foetal thymus. Adult levels of colony-forming cells were achieved within 3 days of birth. In organ cultures of 15-day foetal liver or spleen, B-lymphocyte colony-forming cells developed during a 5-day incubation period, indicating that both organs can function as bursal analogues. Foetal liver colony-forming cells were of small size and generated colonies of cells with a pattern of membrane immunoglobulin similar to colony cells generated by cells from adult animals.

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Selected References

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