Abstract
The anti-dinitrophenol (DNP) antibody response was examined in the 18-week-old offspring of female mice primed to bovine serum albumin (BSA) and in control unprimed animals. Comparisons were made of the response to DNP-BSA, DNP-chicken gamma-globulin (CGG) and DNP-purified protein derivative (PPD) after all offspring had been primed with DNP-CGG at 12 weeks of age. An enhanced anti-DNP antibody response was found to DNP-BSA in mice whose mothers had received BSA. It is suggested that this phenomenon demonstrates the transfer of carrier protein sensitivity from mother to foetus.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Field E. J., Caspary E. A. Is maternal lymphocyte sensitisation passed to the child? Lancet. 1971 Aug 14;2(7720):337–342. doi: 10.1016/s0140-6736(71)90059-6. [DOI] [PubMed] [Google Scholar]
- Gill T. J., 3rd, Kunz H. W., Bernard C. F. Maternal-fetal interaction and immunological memory. Science. 1971 Jun 25;172(3990):1346–1348. doi: 10.1126/science.172.3990.1346. [DOI] [PubMed] [Google Scholar]
- Kindred B., Roelants G. E. Restricted clonal response to DNP in adult offspring of immunized mice: a maternal effect. J Immunol. 1974 Aug;113(2):445–448. [PubMed] [Google Scholar]
- NISONOFF A., WISSLER F. C., LIPMAN L. N., WOERNLEY D. L. Separation of univalent fragments from the bivalent rabbit antibody molecule by reduction of disulfide bonds. Arch Biochem Biophys. 1960 Aug;89:230–244. doi: 10.1016/0003-9861(60)90049-7. [DOI] [PubMed] [Google Scholar]
- PICKERING D. E., KONTAXIS N. E. Thyroid function in the foetus of the macaque monkey (Macaca mulatta). II. Chemical and morphological characteristics of the foetal thyroid gland. J Endocrinol. 1961 Dec;23:267–275. doi: 10.1677/joe.0.0230267. [DOI] [PubMed] [Google Scholar]
- Tuffrey M., Bishun N. P., Barnes R. D. Porosity of the mouse placenta to maternal cells. Nature. 1969 Mar 15;221(5185):1029–1030. doi: 10.1038/2211029a0. [DOI] [PubMed] [Google Scholar]