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. 1977 Feb;32(2):273–278.

Receptors for IgM on murine lymphoid cells.

V Santana
PMCID: PMC1445216  PMID: 321344

Abstract

Murine lymphoid cells from the thymus, lymph node and spleen were shown by indirect immunofluorescence, to bear membrane receptors for purified IgM of human origin. The bond between IgM and the cells took place through the Fc re gion, as demonstrated with isolated fragments of the normal IgM molecule. Two distinct myeloma IgM lacked this biological activity. The cytophilic origin of part of the immunoglobulin usually described on T-cell membranes is discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Anderson C. L., Grey H. M. Receptors for aggregated IgG on mouse lymphocytes: their presence on thymocytes, thymus-derived, and bone marrow-derived lymphocytes. J Exp Med. 1974 May 1;139(5):1175–1188. doi: 10.1084/jem.139.5.1175. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Basten A., Warner N. L., Mandel T. A receptor for antibody on B lymphocytes. II. Immunochemical and electron microscopy characteristics. J Exp Med. 1972 Mar 1;135(3):627–642. doi: 10.1084/jem.135.3.627. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Dickler H. B., Kunkel H. G. Interaction of aggregated -globulin with B lymphocytes. J Exp Med. 1972 Jul 1;136(1):191–196. doi: 10.1084/jem.136.1.191. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Feldmann M., Cone R. E., Marchalonis J. J. Cell interactions in the immune response in vitro. VI. Mediation by T cell surface monomeric IgM. Cell Immunol. 1973 Oct;9(1):1–11. doi: 10.1016/0008-8749(73)90162-7. [DOI] [PubMed] [Google Scholar]
  5. Florent G., Lehman D., Lockhart D., Putnam F. W. Identity of the Fc fragments of pathological and normal human immunoglobulin M. Biochemistry. 1974 Jul 30;13(16):3372–3381. doi: 10.1021/bi00713a030. [DOI] [PubMed] [Google Scholar]
  6. Goldschneider I., Cogen R. B. Immunoglobulin molecules on the surface of activated T lymphocytes in the rat. J Exp Med. 1973 Jul 1;138(1):163–175. doi: 10.1084/jem.138.1.163. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Grey H. M., Colon S., Solomon A., McLaughlin C. L. Immunoglobulin on the surface of human lymphocytes. The detection of kappa chain V region determinants on B cells and not on T cells. J Immunol. 1973 Dec;111(6):1923–1925. [PubMed] [Google Scholar]
  8. Hudson L., Thantrey N., Roitt I. M. The bursa dependence of chicken thymus-derived lymphocyte surface immunoglobulin. Immunology. 1975 Jan;28(1):151–159. [PMC free article] [PubMed] [Google Scholar]
  9. Inman F. P., Ricardo M. J., Jr The association of J chain with the Fc region of human IgM. J Immunol. 1974 Jan;112(1):229–233. [PubMed] [Google Scholar]
  10. Marchalonis J. J., Cone R. E., Atwell J. L. Isolation and partial characterization of lymphocyte surface immunoglobulins. J Exp Med. 1972 Apr 1;135(4):956–971. doi: 10.1084/jem.135.4.956. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Melchers F., Andersson J. IgM in bone marrow-derived lymphocytes. Changes in synthesis, turnover and secretion, and in numbers of molecules on the surface of B cells after mitogenic stimulation. Eur J Immunol. 1974 Mar;4(3):181–188. doi: 10.1002/eji.1830040306. [DOI] [PubMed] [Google Scholar]
  12. Moroz C., Hahn Y. Cell-surface immunoglobulin human thymus cells and its biosynthesis in vitro. Proc Natl Acad Sci U S A. 1973 Dec;70(12):3716–3720. doi: 10.1073/pnas.70.12.3716. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Nossal G. J., Warner N. L., Lewis H., Sprent J. Quantitative features of a sandwich radioimmunolabeling technique for lymphocyte surface receptors. J Exp Med. 1972 Feb 1;135(2):405–428. doi: 10.1084/jem.135.2.405. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Paraskevas F., Lee S. T., Orr K. B., Israels L. G. A receptor for Fc on mouse B-lymphocytes. J Immunol. 1972 May;108(5):1319–1327. [PubMed] [Google Scholar]
  15. Pernis B., Miller J. F., Forni L., Sprent J. Immunoglobulin on activated T cells detected by indirect immunofluorescence. Cell Immunol. 1974 Mar 15;10(3):476–482. doi: 10.1016/0008-8749(74)90139-7. [DOI] [PubMed] [Google Scholar]
  16. Plaut A. G., Tomasi T. B., Jr Immunoglobulin M: pentameric Fcmu fragments released by trypsin at higher temperatures. Proc Natl Acad Sci U S A. 1970 Feb;65(2):318–322. doi: 10.1073/pnas.65.2.318. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Santana V., Turk J. L. Binding of aggregated human immunoglobulin to murine thymocytes and T cells through receptors for the Fc region. Immunology. 1975 Jun;28(6):1173–1178. [PMC free article] [PubMed] [Google Scholar]
  18. Vitetta E. S., Bianco C., Nussenzweig V., Uhr J. W. Cell surface immunoglobulin. IV. Distribution among thymocytes, bone mrrow cells, and their derived populations. J Exp Med. 1972 Jul 1;136(1):81–93. doi: 10.1084/jem.136.1.81. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Webb S. R., Cooper M. D. T cells can bind antigen via cytophilic IgM antibody made by B cells. J Immunol. 1973 Jul;111(1):275–277. [PubMed] [Google Scholar]

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