Skip to main content
NCBI home page
Immunology logoLink to Immunology
. 1976 Sep;31(3):363–369.

Characteristics of the maternal lymphoid response of mice to paternal strain antigens induced by homologous pregnancy.

M G Baines, E A Speers, H Pross, K G Millar
PMCID: PMC1445259  PMID: 17572

Abstract

Mice mated with H-2 incompatible males were shown to have an increased frequency of specific allocluster-forming spleen cells to paternal strain erythrocytes. The time course of the response was similar to that expected following a skin allograft. The graft-versus-host responsiveness of the maternal lymphocytes was generally elevated in the post-partum period in matings with males incompatible at either the H2 locus or non-H2 loci. The implications of these responses with respect to their different lymphocyte mediators and possible interactions are discussed with the view that a B-cell mediated immune response to paternal antigens may be contributory to foetal survival.

Full text

PDF
363

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Baines M. G., Ansell J., McLaren A., Micklem H. S. Maternal immunization to paternal antigens in multiparous mice. J Reprod Fertil. 1975 Feb;42(2):293–299. doi: 10.1530/jrf.0.0420293. [DOI] [PubMed] [Google Scholar]
  2. Baines M. G., Micklem H. S. A method for the quantitation of the localized graft-versus-host response in the mouse by uptake of 125IUdR. Transplantation. 1975 Dec;20(6):512–517. [PubMed] [Google Scholar]
  3. Beer A. E., Billingham R. E., Yang S. L. Maternally induced transplantation immunity, tolerance, and runt disease in rats. J Exp Med. 1972 Apr 1;135(4):808–826. doi: 10.1084/jem.135.4.808. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Beer A. E., Scott J. R., Billingham R. E. Histoincompatibility and maternal immunological status as determinants of fetoplacental weight and litter size in rodents. J Exp Med. 1975 Jul 1;142(1):180–196. doi: 10.1084/jem.142.1.180. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Boyle W. An extension of the 51Cr-release assay for the estimation of mouse cytotoxins. Transplantation. 1968 Sep;6(6):761–764. doi: 10.1097/00007890-196809000-00002. [DOI] [PubMed] [Google Scholar]
  6. Ceppellini R., Bonnard G. D., Coppo F., Miggiano V. C., Pospisil M., Curtoni E. S., Pellegrino M. Transplantation antigens: introductory symposium. Mixed leukocyte cultures and HL-A antigens. I. Reactivity of young fetuses, newborns and mothers at delivery. Transplant Proc. 1971 Mar;3(1):58–63. [PubMed] [Google Scholar]
  7. Duffus W. P., Allan D. The kinetics and morphology of the rosette-forming cell response in the popliteal lymph nodes of rats. Immunology. 1971 Mar;20(3):345–361. [PMC free article] [PubMed] [Google Scholar]
  8. Feldman J. D. Immunological enhancement: a study of blocking antibodies. Adv Immunol. 1972;15:167–214. doi: 10.1016/s0065-2776(08)60685-9. [DOI] [PubMed] [Google Scholar]
  9. GOODLIN R. C., HERZENBERG L. A. PREGNANCY INDUCED HEMAGGLUTININS TO PATERNAL H-2 ANTIGENS IN MULTIPAROUS MICE. Transplantation. 1964 May;2:357–361. doi: 10.1097/00007890-196405000-00004. [DOI] [PubMed] [Google Scholar]
  10. Hellström K. E., Hellström I., Brawn J. Abrogation of cellular immunity to antigenically foreign mouse embryonic cells by a serum factor. Nature. 1969 Nov 29;224(5222):914–915. doi: 10.1038/224914a0. [DOI] [PubMed] [Google Scholar]
  11. James D. A. Some effects of immunological factors on gestation in mice. J Reprod Fertil. 1967 Oct;14(2):265–275. doi: 10.1530/jrf.0.0140265. [DOI] [PubMed] [Google Scholar]
  12. Jones E., Curzen P., Gaugas J. M. Suppressive activity of pregnancy plasma on the mixed lymphocyte reaction. J Obstet Gynaecol Br Commonw. 1973 Jul;80(7):603–607. doi: 10.1111/j.1471-0528.1973.tb16033.x. [DOI] [PubMed] [Google Scholar]
  13. KALISS N., DAGG M. K. IMMUNE RESPONSE ENGENDERED IN MICE BY MULTIPARITY. Transplantation. 1964 May;2:416–425. doi: 10.1097/00007890-196405000-00011. [DOI] [PubMed] [Google Scholar]
  14. Lengerová A., Viklický V., Rejzková J. Specificity of the reaction between allocluster-forming cells and target erythrocytes. Folia Biol (Praha) 1971;17(6):405–409. [PubMed] [Google Scholar]
  15. Maroni E. S., Parrott D. M. Progressive increase in cell-mediated immunity against paternal transplantation antigens in parous mice after multiple pregnancies. Clin Exp Immunol. 1973 Feb;13(2):253–262. [PMC free article] [PubMed] [Google Scholar]
  16. Micklem H. S., Asfi C., Staines N. A., Anderson N. Quantitative study of cells reacting to skin allografts. Nature. 1970 Aug 29;227(5261):947–949. doi: 10.1038/227947a0. [DOI] [PubMed] [Google Scholar]
  17. Palm J. Maternal-fetal interactions and histocompatibility antigen polymorphisms. Transplant Proc. 1970 Mar;2(1):162–173. [PubMed] [Google Scholar]
  18. Palm J. Proceedings: Maternal-fetal histoincompatibility in rats: an escape from adversity. Cancer Res. 1974 Aug;34(8):2061–2065. [PubMed] [Google Scholar]
  19. STIMPFLING J. H. METHODS FOR DETECTION OF HEMAGGLUTININS IN MOUSE ISOANTISERA. Methods Med Res. 1964;10:22–26. [PubMed] [Google Scholar]
  20. Searle R. F., Johnson M. H., Billington W. D., Elson J., Clutterbuck-Jackson S. Investigation of H-2 and non-H-2 antigens on the mouse blastocyst. Transplantation. 1974 Aug;18(2):136–141. doi: 10.1097/00007890-197408000-00006. [DOI] [PubMed] [Google Scholar]
  21. Snell G. D., Démant P., Cherry M. Hemagglutination and cytotoxic studies of H-2. I. H-2.1 and related specificities in the EK crossover regions. Transplantation. 1971 Mar;11(3):210–237. doi: 10.1097/00007890-197103000-00002. [DOI] [PubMed] [Google Scholar]
  22. Sörén L. Immunological reactivity of lymphocytes in multiparous females after strain specific matings. Nature. 1967 Feb 11;213(5076):621–622. doi: 10.1038/213621a0. [DOI] [PubMed] [Google Scholar]
  23. Viklický V., Lengerová A., Matousek V., Doubelík M. The frequency of "Allocluster-forming cells" in the lymph nodes of skin-grafted mice as a function of the histocompatibility barrier. Folia Biol (Praha) 1971;17(3):156–162. [PubMed] [Google Scholar]
  24. Wilson J. D. The relationship of antibody-forming cells to rosette-forming cells. Immunology. 1971 Aug;21(2):233–245. [PMC free article] [PubMed] [Google Scholar]

Articles from Immunology are provided here courtesy of British Society for Immunology

RESOURCES