Abstract
The age-dependent change of the levels of five classes of immunoglobulin in mouse serum were investigated. Between 3 and 12 months after birth, the major IgG subclass of BALB/c was IgG1, while that of C57BL/6 was IgG2b. This difference was the same in the sera from hyperimmunized or germ-free animals.
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Selected References
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- Bankhurst A. D., Lambert P. H., Miescher P. A. Studies on the thymic dependence of the immunoglobulin classes of the mouse (38570). Proc Soc Exp Biol Med. 1975 Feb;148(2):501–504. doi: 10.3181/00379727-148-38570. [DOI] [PubMed] [Google Scholar]
- Bloemmen J., Eyssen H. Immunoglobulin levels of sera of genetically thymusless (nude) mice. Eur J Immunol. 1973 Feb;3(2):117–118. doi: 10.1002/eji.1830030213. [DOI] [PubMed] [Google Scholar]
- Kalpaktsoglou P. K., Hong R., Good R. A. The five classes of immunoglobulins in normal C3H and BALB/c mice. Immunology. 1973 Feb;24(2):303–314. [PMC free article] [PubMed] [Google Scholar]
- Katz D. H., Benacerraf B. The regulatory influence of activated T cells on B cell responses to antigen. Adv Immunol. 1972;15:1–94. doi: 10.1016/s0065-2776(08)60683-5. [DOI] [PubMed] [Google Scholar]
- Mancini G., Carbonara A. O., Heremans J. F. Immunochemical quantitation of antigens by single radial immunodiffusion. Immunochemistry. 1965 Sep;2(3):235–254. doi: 10.1016/0019-2791(65)90004-2. [DOI] [PubMed] [Google Scholar]
- Ono S., Natsu-ume S., Migita S. Alteration of cell-surface antigenicity of the mouse plasmacytoma. I. Immunologic characterization of surface antigens masked during successive transplantations. J Natl Cancer Inst. 1975 Sep;55(3):569–577. doi: 10.1093/jnci/55.3.569. [DOI] [PubMed] [Google Scholar]
- POTTER M., ROBERTSON C. L. Development of plasma-cell neoplasms in BALB/c mice after intraperitoneal injection of paraffin-oil adjuvant, heart-killed Staphylococcus mixtures. J Natl Cancer Inst. 1960 Oct;25:847–861. doi: 10.1093/jnci/25.4.847. [DOI] [PubMed] [Google Scholar]
- Pritchard H., Riddaway J., Micklem H. S. Immune responses in congenitally thymus-less mice. II. Quantitative studies of serum immunoglobulins, the antibody response to sheep erythrocytes, and the effect of thymus allografting. Clin Exp Immunol. 1973 Jan;13(1):125–138. [PMC free article] [PubMed] [Google Scholar]
- RASK-NIELSEN R., CHRISTENSEN H. E., CLAUSEN J. Electrophoretic and morphologic studies of a transplantable reticulum-cell neoplasm in mice inducing amyloidosis. J Natl Cancer Inst. 1960 Aug;25:315–349. [PubMed] [Google Scholar]
- Rádl J., Hollander C. F. Homogeneous immunoglobulins in sera of mice during aging. J Immunol. 1974 Jun;112(6):2271–2273. [PubMed] [Google Scholar]
- SELL S., FAHEY J. L. RELATIONSHIP BETWEEN GAMMA-GLOBULIN METABOLISM AND LOW SERUM GAMMA-GLOBULIN IN GERMFREE MICE. J Immunol. 1964 Jul;93:81–87. [PubMed] [Google Scholar]
- Schimpl A., Wecker E. Stimulation of IgG antibody response in vitro by T cell-replacing factor. J Exp Med. 1973 Feb 1;137(2):547–552. doi: 10.1084/jem.137.2.547. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Sugai S., Pillarisetty R., Talal N. Monoclonal macroglobulinemia in NZB-NZW F1 mice. J Exp Med. 1973 Oct 1;138(4):989–1002. doi: 10.1084/jem.138.4.989. [DOI] [PMC free article] [PubMed] [Google Scholar]
- WOSTMANN B. S. Recent studies on the serum proteins of germfree animals. Ann N Y Acad Sci. 1961 Aug 31;94:272–283. doi: 10.1111/j.1749-6632.1961.tb35547.x. [DOI] [PubMed] [Google Scholar]
- Waldmann H., Munro A. J. T cell dependence of B cell unresponsiveness in vitro. Eur J Immunol. 1974 Jun;4(6):410–416. doi: 10.1002/eji.1830040605. [DOI] [PubMed] [Google Scholar]
- Wanebo H. J., Gallmeier W. M., Boyse E. A., Old L. J. Paraproteinemia and reticulum cell sarcoma in an inbred mouse strain. Science. 1966 Nov 18;154(3751):901–903. doi: 10.1126/science.154.3751.901. [DOI] [PubMed] [Google Scholar]