Skip to main content
Immunology logoLink to Immunology
. 1977 Apr;32(4):419–425.

Rat lymphocyte differentiation antigens detected by rabbit antiserum to thymocytes and leukaemic cells.

A Thompson, R J Morris
PMCID: PMC1445490  PMID: 75837

Abstract

The lymphocyte differentiation antigens detected by rabbit antisera to rat thymocytes and leukaemic cells have been investigated. Thy-1 was the only such antigen detected by the anti-thymocyte serum, which was predominately directed to two xenoantigenic determinants rather than the Thy-1.1 determinant on this molecule. Two additional antigens were recognized by the anti-leukaemia serum. One of these was found on thymocytes and peripheral lymphocytes, but only on 1 per cent of bone marrow cells. The other was found not only on lymphocytes, but also on the nucleated myeloid and erythroid cells of bone marrow.

Full text

PDF
419

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Acton R. T., Morris R. J., Williams A. F. Estimation of the amount and tissue distribution of rat Thy-1.1 antigen. Eur J Immunol. 1974 Sep;4(9):598–602. doi: 10.1002/eji.1830040904. [DOI] [PubMed] [Google Scholar]
  2. Barclay A. N., Letarte-Muirhead M., Williams A. F. Purification of the Thy-1 molecule from rat brain. Biochem J. 1975 Dec;151(3):699–706. doi: 10.1042/bj1510699. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Bron C., Sauser D. Heterologous antiserum to mouse thymus-derived lymphocytes. J Immunol. 1973 Feb;110(2):384–389. [PubMed] [Google Scholar]
  4. Colley D. G., Malakian A., Waksman B. H. Cellular differentiation in the thymus. II. Thymus-specific antigens in rat thymus and peripheral lymphoid cells. J Immunol. 1970 Mar;104(3):585–592. [PubMed] [Google Scholar]
  5. Dibley M., Dorsch S., Roser B. T cell leukaemia in the rat: the pathophysiology. Pathology. 1975 Jul;7(3):219–235. doi: 10.3109/00313027509094412. [DOI] [PubMed] [Google Scholar]
  6. Jensenius J. C., Williams A. F. The binding of anti-immunoglobulin antibodies to rat thymocytes and thoracic duct lymphocytes. Eur J Immunol. 1974 Feb;4(2):91–97. doi: 10.1002/eji.1830040207. [DOI] [PubMed] [Google Scholar]
  7. LOWRY O. H., ROSEBROUGH N. J., FARR A. L., RANDALL R. J. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951 Nov;193(1):265–275. [PubMed] [Google Scholar]
  8. Letarte-Muirhead M., Barclay A. N., Williams A. F. Purification of the Thy-1 molecule, a major cell-surface glycoprotein of rat thymocytes. Biochem J. 1975 Dec;151(3):685–697. doi: 10.1042/bj1510685. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Morris R. J., Letarte-Muirhead M., Williams A. F. Analysis in deoxycholate of three antigenic specificities associated with the rat Thy-1 molecule. Eur J Immunol. 1975 Apr;5(4):282–285. doi: 10.1002/eji.1830050413. [DOI] [PubMed] [Google Scholar]
  10. Morris R. J., Williams A. F. Antigens on mouse and rat lymphocytes recognized by rabbit antiserum against rat brain: the quantitative analysis of a xenogeneic antiserum. Eur J Immunol. 1975 Apr;5(4):274–281. doi: 10.1002/eji.1830050412. [DOI] [PubMed] [Google Scholar]
  11. Muirhead M. L., Action R. T., Williams A. F. Preliminary characterization of Thy-1.1 and Ag-B antigens from rat tissues solubilized in detergents. Biochem J. 1974 Oct;143(1):51–61. doi: 10.1042/bj1430051. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Roser B., Ford W. L. Prolonged lymphocytopenia in the rat. The depletion of blood and thoracic duct lymphocyte populations following injection of -emitting colloids into the spleen or lymph nodes. Aust J Exp Biol Med Sci. 1972 Apr;50(2):165–184. [PubMed] [Google Scholar]
  13. Sauser D., Anckers C., Bron C. Isolation of mouse thymus-derived lymphocyte specific surface antigens. J Immunol. 1974 Aug;113(2):617–624. [PubMed] [Google Scholar]
  14. Williams A. F. Assays for cellular antigens in the presence of detergents. Eur J Immunol. 1973 Oct;3(10):628–632. doi: 10.1002/eji.1830031007. [DOI] [PubMed] [Google Scholar]

Articles from Immunology are provided here courtesy of British Society for Immunology

RESOURCES