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. 1977 Dec;33(6):865–872.

Lymphocyte surface IgD and IgM in Macaca monkeys: ontogeny, tissue distribution and occurrence on individual lymphocytes.

L N Martin, G A Leslie
PMCID: PMC1445531  PMID: 412779

Abstract

A proportion of lymphocytes in blood, spleen and lymph nodes of nonhuman primates had immunoglobulin on their surfaces detectable by fluorescent antibody to human IgM and IgD. The majority of the individual lymphocytes having either IgM or IgD on their surfaces possessed both classes of immunoglobulin. Lymphocyte surface IgD was capped independently of surface IgM on the same cell when incubated at 37 degrees with anti-IgD. Lymphocytes with surface IgM and/or IgD were present in blood at birth and the percentages over the first 6 months of life were increased compared to older monkeys. A corona of cells faintly positive for both IgM and IgD was observed around germinal centres of both lymph nodes and spleen.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Abney E. R., Hunter I. R., Parkhouse R. M. Preparation and characterisation of an antiserum to the mouse candidate for immunoglobulin D. Nature. 1976 Feb 5;259(5542):404–406. doi: 10.1038/259404a0. [DOI] [PubMed] [Google Scholar]
  2. Abney E. R., Parkhouse R. M. Candidate for immunoglobulin D present on murine B lymphocytes. Nature. 1974 Dec 13;252(5484):600–602. doi: 10.1038/252600a0. [DOI] [PubMed] [Google Scholar]
  3. Dukor P., Bianco C., Nussenzweig V. Tissue localization of lymphocytes bearing a membrane receptor for antigen-antibody-complement complexes. Proc Natl Acad Sci U S A. 1970 Oct;67(2):991–997. doi: 10.1073/pnas.67.2.991. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Finkelman F. D., van Boxel J. A., Asofsky R., Paul W. E. Cell membrane IgD: demonstration of IgD on human lymphocytes by enzyme-catalyzed iodination and comparison with cell surface Ig of mouse, guinea pig, and rabbit. J Immunol. 1976 Apr;116(4):1173–1181. [PubMed] [Google Scholar]
  5. Fu S. M., Winchester R. J., Kunkel H. G. Similar idiotypic specificity for the membrane IgD and IgM of human B lymphocytes. J Immunol. 1975 Jan;114(1 Pt 1):250–252. [PubMed] [Google Scholar]
  6. Gupta S., Pahwa R., O'Reilly R., Good R. A., Siegal F. P. Ontogeny of lymphocyte subpopulations in human fetal liver. Proc Natl Acad Sci U S A. 1976 Mar;73(3):919–922. doi: 10.1073/pnas.73.3.919. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Howard J. C., Hunt S. V., Gowans J. L. Identification of marrow-derived and thymus-derived small lymphocytes in the lymphoid tissue and thoracic duct lymph of normal rats. J Exp Med. 1972 Feb 1;135(2):200–219. doi: 10.1084/jem.135.2.200. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. James K. K., Hurtubise P. E., MacPherson C. R., Murphy S. G. Human lymphocyte membrane immunoglobulin as a reflection of maturation. J Immunol. 1974 Aug;113(2):698–701. [PubMed] [Google Scholar]
  9. Kermani-Arab V., Burger D. R., Leslie G. A. Structure and biologic functions of human IgD. X. Enhancement of PHA responsiveness by anti-delta-activated lymphocytes. J Immunol. 1976 Aug;117(2):467–470. [PubMed] [Google Scholar]
  10. Martin L. N., Leslie G. A., Hindes R. Lymphocyte surface IgD and IgM in non-human primates. Int Arch Allergy Appl Immunol. 1976;51(3):320–329. doi: 10.1159/000231606. [DOI] [PubMed] [Google Scholar]
  11. Melcher U., Uhr J. W. Cell surface immunoglobulin. XVI. Polypeptide chain structure of mouse IgM and IgD-like molecule. J Immunol. 1976 Feb;116(2):409–415. [PubMed] [Google Scholar]
  12. Melcher U., Vitetta E. S., McWilliams M., Lamm M. E., Phillips-Quagliata J. M., Uhr J. W. Cell surface immunoglobulin. X. Identification of an IgD-like molecule on the surface of murine splenocytes. J Exp Med. 1974 Nov 1;140(5):1427–1431. doi: 10.1084/jem.140.5.1427. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. NOSSAL G. J., ADA G. L., AUSTIN C. M. ANTIGENS IN IMMUNITY. IV. CELLULAR LOCALIZATION OF 125-I- AND 131-I-LABELLED FLAGELLA IN LYMPH NODES. Aust J Exp Biol Med Sci. 1964 Jun;42:311–330. [PubMed] [Google Scholar]
  14. Neiburger J. B., Neiburger R. G., Richardson S. T., Grosfeld J. L., Baehner R. L. Distribution of T and B lymphocytes in lymphoid tissue of infants and children. Infect Immun. 1976 Jul;14(1):118–121. doi: 10.1128/iai.14.1.118-121.1976. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Pernis B., Brouet J. C., Seligmann M. IgD and IgM on the membrane of lymphoid cells in macroglobulinemia. Evidence for identity of membrane IgD and IgM antibody activity in a case with anti-IgG receptors. Eur J Immunol. 1974 Nov;4(11):776–778. doi: 10.1002/eji.1830041114. [DOI] [PubMed] [Google Scholar]
  16. Rowe D. S., Hug K., Forni L., Pernis B. Immunoglobulin D as a lymphocyte receptor. J Exp Med. 1973 Oct 1;138(4):965–972. doi: 10.1084/jem.138.4.965. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Salsano F., Froland S. S., Natvig J. B., Michaelsen T. E. Same idiotype of B-lymphocyte membrane IgD and IgM. Formal evidence for monoclonality of chronic lymphocytic leukemia cells. Scand J Immunol. 1974;3(6):841–846. doi: 10.1111/j.1365-3083.1974.tb01321.x. [DOI] [PubMed] [Google Scholar]
  18. Van Boxel J. A., Paul W. E., Terry W. D., Green I. Communications. IgD-bearing human lymphocytes. J Immunol. 1972 Sep;109(3):648–651. [PubMed] [Google Scholar]
  19. Vitetta E. S., Melcher U., McWilliams M., Lamm M. E., Phillips-Quagliata J. M., Uhr J. W. Cell surface immunoglobulin. XI. The appearance of an IgD-like molecule on murine lymphoid cells during ontogeny. J Exp Med. 1975 Jan 1;141(1):206–215. doi: 10.1084/jem.141.1.206. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Vitetta E. S., Uhr J. W. Immunoglobulin-receptors revisited. Science. 1975 Sep 19;189(4207):964–969. doi: 10.1126/science.1083069. [DOI] [PubMed] [Google Scholar]
  21. Vossen J. M. Membrane-associated immunoglobulin determinants on bone marrow and blood lymphocytes in the pediatric age group and on fetal tissues. Ann N Y Acad Sci. 1975 Jun 30;254:262–279. doi: 10.1111/j.1749-6632.1975.tb29176.x. [DOI] [PubMed] [Google Scholar]
  22. Winchester R. J., Fu S. M., Hoffman T., Kunkel H. G. IgG on lymphocyte surfaces; technical problems and the significance of a third cell population. J Immunol. 1975 Apr;114(4):1210–1212. [PubMed] [Google Scholar]

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