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. 1977 Dec;33(6):787–795.

Immunity to Trichinella spiralis. I. Transfer of resistance by two classes of lymphocytes.

E D Crum, D D Despommier, D D McGregor
PMCID: PMC1445543  PMID: 304035

Abstract

Rats can be solidly immunized against Trichinella spiralis by a series of methyridine-terminated oral infections with T. spiralis larvae. Injections of thoracic duct lymphocytes (TDL) obtained from such animals can protect normal rats against a Trichinella challenge. The protective cells belong to two populations which differ with respect to their adherence to affinity columns prepared with rabbit antibody to rat F(ab')2. Immune lymphocytes in the column-adherent B cell fraction are inhibited by vinblastine, whereas those in the non-adherent, T cell fraction are resistant to this drug. The above observations suggest that acquired resistance to T. spiralis is mediated by two classes of lymphocytes: B cells which are delivered to the thoracic duct and hence to the blood while still in active cycle, and T cells which have a potentially long life-span and presumably belong to a pool of recirculating small lymphocytes.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. CAMPBELL C. H. The antigenic role of the excretions and secretions of Trichinella spiralis in the production of immunity in mice. J Parasitol. 1955 Oct;41(5):483–491. [PubMed] [Google Scholar]
  2. CHIPMAN P. B. The antigenic role of the excretions and secretions of adult Trichinella spiralis in the production of immunity in mice. J Parasitol. 1957 Dec;43(6):593–598. [PubMed] [Google Scholar]
  3. Crum E. D., McGregor D. D. Functional properties of T and B cells isolated by affinity chromatography from rat thoracic duct lymph. Cell Immunol. 1976 May;23(2):211–222. doi: 10.1016/0008-8749(76)90187-8. [DOI] [PubMed] [Google Scholar]
  4. Denham D. A. Immunity to Trichinella spiralis. I. The immunity produced by mice to the first four days of the intestinal phase of the infection. Parasitology. 1966 May;56(2):323–327. [PubMed] [Google Scholar]
  5. Denham D. A. Studies with methyridine and Trichinella spiralis. I. Effect upon the intestinal phase in mice. Exp Parasitol. 1965 Aug;17(1):10–14. doi: 10.1016/0014-4894(65)90003-2. [DOI] [PubMed] [Google Scholar]
  6. Despommier D. D. Immunogenicity of the newborn larva of Trichinella spiralis. J Parasitol. 1971 Jun;57(3):531–534. [PubMed] [Google Scholar]
  7. Despommier D. D., McGregor D. D., Crum E. D., Carter P. B. Immunity to Trichinella spiralis. II. Expression of immunity against adult worms. Immunology. 1977 Dec;33(6):797–805. [PMC free article] [PubMed] [Google Scholar]
  8. Despommier D. D., Müller M. The stichosome and its secretion granules in the mature muscle larva of Trichinella spiralis. J Parasitol. 1976 Oct;62(5):775–785. [PubMed] [Google Scholar]
  9. Despommier D. D., Wostmann B. S. Trichinella spiralis: immune elimination in mice. Exp Parasitol. 1969 Apr;24(2):243–250. doi: 10.1016/0014-4894(69)90161-1. [DOI] [PubMed] [Google Scholar]
  10. Gowans J. L., Uhr J. W. The carriage of immunological memory by small lymphocytes in the rat. J Exp Med. 1966 Nov 1;124(5):1017–1030. doi: 10.1084/jem.124.5.1017. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Koster F. T., McGregor D. D., Mackaness G. B. The mediator of cellular immunity. II. Migration of immunologically committed lymphocytes into inflammatory exudates. J Exp Med. 1971 Feb 1;133(2):400–409. doi: 10.1084/jem.133.2.400. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Kozek W. J. The molting pattern in Trichinella spiralis. I. A light microscope study. J Parasitol. 1971 Oct;57(5):1015–1028. [PubMed] [Google Scholar]
  13. Love R. J., Ogilvie B. M., McLaren D. J. The immune mechanism which expels the intestinal stage of Trichinella spiralis from rats. Immunology. 1976 Jan;30(1):7–15. [PMC free article] [PubMed] [Google Scholar]
  14. MILLS C. K., KENT N. H. EXERETIONS AND SECRETIONS OF TRICHINELLA SPIRALIS AND THEIR ROLE IN IMMUNITY. Exp Parasitol. 1965 Jun;16:300–310. doi: 10.1016/0014-4894(65)90051-2. [DOI] [PubMed] [Google Scholar]
  15. McGregor D. D., Koster F. T., Mackaness G. B. The mediator of cellular immunity. I. The life-span and circulation dynamics of the immunologically committed lymphocyte. J Exp Med. 1971 Feb 1;133(2):389–399. doi: 10.1084/jem.133.2.389. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. McGregor D. D., Logie P. S. The mediator of cellular immunity. VI. Effect of the antimitotic drug vinblastine on the mediator of cellular resistance to infection. J Exp Med. 1973 Mar 1;137(3):660–674. doi: 10.1084/jem.137.3.660. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. McGregor D. D., Mackaness G. B. The properities of lymphocytes which carry immunologic memory of phiX 174. J Immunol. 1975 Jan;114(1 Pt 2):336–342. [PubMed] [Google Scholar]
  18. ZAIMAN H., WILSON J. D., RUBEL J., STONEY J. M. Studies on the nature of immunity to Trichinella spiralis in parabiotic rats. IV. The immune response in uninfected parabiotic rats surgically separated from their mates 2,3,4, or 5 days after the latter received an immunizing infection. Am J Hyg. 1954 Jan;59(1):39–51. doi: 10.1093/oxfordjournals.aje.a119622. [DOI] [PubMed] [Google Scholar]

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