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. 1974 Aug;27(2):299–304.

Studies on thymus products

III. Epithelial origin of the serum thymic factor

Mireille Dardenne, Martine Papiernik, J-F Bach, O Stutman
PMCID: PMC1445565  PMID: 4421188

Abstract

Serum thymic factor (TF) has been tested by its action on spleen rosette-forming cells from adult thymectomized mice. It has been confirmed in a blind study using coded serum samples that TF disappeared early after adult thymectomy and reappeared after grafting a thymus, either as a free graft or enclosed in cell impermeable diffusion chambers. Similar reconstitution was also obtained by grafting a non-lymphoid epithelial thymoma or pure epithelial thymus, obtained by in vivo incubation of a thymus within a diffusion chamber in an intermediate host. Conversely, TF levels were not restored in thymectomized animals treated with dispersed spleen cells or with dispersed thymic lymphocytes.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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