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. 1977 Sep;33(3):423–432.

A re-evaluation of the role of macrophages in carrageenan-induced immunosuppression.

V M Rumjanek, S R Watson, V S Sljivić
PMCID: PMC1445637  PMID: 332622

Abstract

Administration of a single dose of 1 mg carrageenan to mice cause a temporary blockade of hepatic phagocytosis of 51Cr-labelled sheep erythrocytes (SRBC) and a prolonged reduction in the number of splenic plaque-forming cells (PFC) against SRBC. The in vitro responses to phytohaemagglutinin (PHA) and SRBC were also suppressed, whereas the response to the T cell-independent antigen DNP-Ficoll was not affected. Other in vitro experiments have shown that responses of normal cells can be actively suppressed by macrophages from carrageenan-treated mice and the possible mechanisms of this suppression are discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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