Abstract
The duration of the inductive effect of an antigen (alum-precipitated trinitrophenyl-keyhole limpet haemocyanin) was measured, in the presence and absence of responding spleen cells, by transfering a test population of spleen cells to irradiated mice at various times relative to antigen injection. Using allotype-congenic mice, the response of a test (Iga) population was estimated in the presence of responding (Igb) cells. In the absence of responding cells the inductive effect fell to 10% of the peak value in 9-10 days, but in their presence it reached this level in less than 5 days. Removal of T cells from the responding (Igb) population reduced their suppressive efficacy. It was concluded that B lymphocyte recruitment is curtailed not by the elimination of antigen but by an active suppressor mechanism involving suppressor T cells.
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Selected References
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- Arrenbrecht S., Mitchell G. F. T cell-dependent helper and suppressive influences in an adoptive IgG antibody response. Immunology. 1975 Mar;28(3):485–495. [PMC free article] [PubMed] [Google Scholar]
- Basten A., Miller J. F., Johnson P. T cell-dependent suppression of an anti-hapten antibody response. Transplant Rev. 1975;26:130–169. doi: 10.1111/j.1600-065x.1975.tb00178.x. [DOI] [PubMed] [Google Scholar]
- Cantor H., Shen F. W., Boyse E. A. Separation of helper T cells from suppressor T cells expressing different Ly components. II. Activation by antigen: after immunization, antigen-specific suppressor and helper activities are mediated by distinct T-cell subclasses. J Exp Med. 1976 Jun 1;143(6):1391–1340. doi: 10.1084/jem.143.6.1391. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Elson C. J., Jablonska K. F., Taylor R. B. Functional half-life of virgin and primed B lymphocytes. Eur J Immunol. 1976 Sep;6(9):634–638. doi: 10.1002/eji.1830060908. [DOI] [PubMed] [Google Scholar]
- Elson C. J., Taylor R. B. Permanent hapten-specific tolerance in B lymphocytes. Immunology. 1975 Mar;28(3):543–552. [PMC free article] [PubMed] [Google Scholar]
- Elson C. J., Taylor R. B. The suppressive effect of carrier priming on the response to a hapten-carrier conjugate. Eur J Immunol. 1974 Oct;4(10):682–687. doi: 10.1002/eji.1830041009. [DOI] [PubMed] [Google Scholar]
- Ford W. L. Duration of the inductive effect of sheep erythrocytes on the recruitment of lymphocytes in the rat. Immunology. 1968 Oct;15(4):609–617. [PMC free article] [PubMed] [Google Scholar]
- Ford W. L. Lymphocyte migration and immune responses. Prog Allergy. 1975;19:1–59. doi: 10.1159/000313381. [DOI] [PubMed] [Google Scholar]
- Golub E. S. Brain-associated theta antigen: reactivity of rabbit anti-mouse brain with mouse lymphoid cells. Cell Immunol. 1971 Aug;2(4):353–361. doi: 10.1016/0008-8749(71)90070-0. [DOI] [PubMed] [Google Scholar]
- Julius M. H., Simpson E., Herzenberg L. A. A rapid method for the isolation of functional thymus-derived murine lymphocytes. Eur J Immunol. 1973 Oct;3(10):645–649. doi: 10.1002/eji.1830031011. [DOI] [PubMed] [Google Scholar]
- Klinman N. R., Taylor R. B. General methods for the study of cells and serum during the immune response: the response to dinitrophenyl in mice. Clin Exp Immunol. 1969 Apr;4(4):473–487. [PMC free article] [PubMed] [Google Scholar]
- Strober S., Dilley J. Maturation of B lymphocytes in the rat. I. Migration pattern, tissue distribution, and turnover rate of unprimed and primed B lymphocytes involved in the adoptive antidinitrophenyl response. J Exp Med. 1973 Dec 1;138(6):1331–1344. doi: 10.1084/jem.138.6.1331. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Strober S. Immune function cell surface characteristics and maturation of B cell subpopulations. Transplant Rev. 1975;24:84–112. doi: 10.1111/j.1600-065x.1975.tb00166.x. [DOI] [PubMed] [Google Scholar]