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. 1974 Nov;27(5):887–893.

The effect of bacterial adjuvants on allograft survival after anti-lymphocyte serum (ALS) and donor bone marrow in mice

A W Clark, A P Monaco
PMCID: PMC1445680  PMID: 4373388

Abstract

An injection of a low dose of donor-type bone marrow cells causes specific added survival of skin allografts on antilymphocyte serum (ALS) treated mice over that seen in mice given only ALS. The effects of single injections of Bordetella pertussis, Bacillus Calmette—Guerin (BCG) and Corynebacterium parvum were studied at various times in this enhancing system. All three agents abrogated the prolongation when given 5 days after grafting but B. pertussis produced a striking increase in prolongation when given 7 days before skin grafting with ALS and subsequent bone marrow. This effect was not found with BCG or C. parvum. The unique graft-prolonging ability of B. pertussis may be related to the changes it produces in the regional nodes.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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