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. 1974 Dec;27(6):1009–1022.

Activity of the reticuloendothelial system and the antibody response

III. The fate of type III pneumococcal polysaccharide and the antibody response*

V S Šljivić, G W Warr
PMCID: PMC1445702  PMID: 4156026

Abstract

Pretreatment of mice with stilboestrol was shown to reduce the splenic direct PFC response to low, but not to high, immunizing doses of SIII. The fate of 125I-labelled SIII in control and stilboestrol-treated mice over a period of 3 weeks was observed. Stilboestrol-treated mice showed enhanced rate of clearance from the blood and hepatic uptake of 125I-labelled SIII, and a consistently depressed level of circulating 125I-labelled SIII. No consistent differences in splenic uptake of SIII between control and stilboestrol-treated mice were observed, but the excretion of radioactivity appeared to be slower in the latter group. The altered pattern of blood clearance and liver uptake of SIII in stilboestrol-treated mice is consistent with the potent stimulation of RES phagocytic activity induced by this agent, and it is suggested that the increased sequestration of SIII in stilboestrol-treated mice may be related to the observed effects of stilboestrol on the antibody response to this antigen.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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