Abstract
In two consecutive studies, eighteen and forty-one normal subjects were given a standard tuberculin skin test of 1 tuberculin unit (0.02 mug of PPD). Two days later another skin test was given. Readings of the skin reactions showed that subjects exhibiting strongly positive skin reactions in their primary skin tests showed a significantly smaller indurations in their primary skin tests tended to have equal or larger areas of induration after the secondary skin tests. These observations are discussed in relation to the possible existence of regulatory mechanisms of cell-mediated immune reactions.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- BRODY J. A., OVERFIELD T., HAMMES L. M. DEPRESSION OF THE TUBERCULIN REACTION BY VIRAL VACCINES. N Engl J Med. 1964 Dec 17;271:1294–1296. doi: 10.1056/NEJM196412172712505. [DOI] [PubMed] [Google Scholar]
- Donald D., Beck J. S. Antigen-binding small lymphocytes in delayed hypersensitivity to tuberculin. Nature. 1971 May 21;231(5299):183–184. doi: 10.1038/231183a0. [DOI] [PubMed] [Google Scholar]
- Dwyer J. M., Kantor F. S. Regulation of delayed hypersensitivity. Failure to transfer delayed hypersensitivity to desensitized guinea pigs. J Exp Med. 1973 Jan 1;137(1):32–41. doi: 10.1084/jem.137.1.32. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Haider S., Coutinho M. de L., Emond R. T., Sutton R. N. Tuberculin anergy and infectious mononucleosis. Lancet. 1973 Jul 14;2(7820):74–74. doi: 10.1016/s0140-6736(73)93265-0. [DOI] [PubMed] [Google Scholar]
- Hjort T., Beutner E. H., Witebsky E. Uptake of labelled antigens by lymphocytes of rabbits with delayed hypersensitivity reactions. Int Arch Allergy Appl Immunol. 1968;33(4):337–352. doi: 10.1159/000230051. [DOI] [PubMed] [Google Scholar]
- Jacobsson H., Blomgren H. Evidence for a loss of recirculating capacity of T-cells after antigenic stimulation. Clin Exp Immunol. 1973 Mar;13(3):439–453. [PMC free article] [PubMed] [Google Scholar]
- Steward A. M. Tuberculin reaction in cancer patients, "Mantoux release," and lymphosuppressive-stimulatory factors. J Natl Cancer Inst. 1973 Mar;50(3):625–632. doi: 10.1093/jnci/50.3.625. [DOI] [PubMed] [Google Scholar]
- Thestrup-Pedersen K. Temporary suppression of lymphocyte transformation after tuberculin skin testing. Immunology. 1974 Dec;27(6):965–971. [PMC free article] [PubMed] [Google Scholar]
- Zappi E., Nemirovsky M., Shulman S. Contralateral epididymo-orchitis after cryo-injury to the male rabbit gonad. Immunology. 1973 Nov;25(5):891–903. [PMC free article] [PubMed] [Google Scholar]