Skip to main content
PMC home page
Immunology logoLink to Immunology
. 1975 Apr;28(4):621–628.

Independent appearance of anti-thymocyte and anti-RNA antibodies in NZB/NZW F1 mice.

R Goldblum, R Pillarisetty, N Talal
PMCID: PMC1445848  PMID: 1080129

Abstract

NZB and NZB/NZW (B/W) mice were studied for natural thymocytoxic autoantibody(NTA) and antibody to reovirus RNA by cytotoxicity and radioimmunoassay respectively.NZB mice developed NTA by 2-3 months of age. RNA antibodies appeared later if atall. NTA and anti-RNA were present in B/W mice starting at 4-5 months and increased in frequency with age. Either activity could appear first and could be present without the other. Thus, all four possible patterns of autoantibody occurrence were found. NTA and anti-RNA in 12-month B/W sera were separable by sucrose density gradient ultracentrifugation; NTA is a 19S IgM antibody whereas anti-RNA is 7S.

Full text

PDF

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Attias M. R., Sylvester R. A., Talal N. Filter radioimmunoassay for antibodies to reovirus RNA in systemic lupus erythematosus. Arthritis Rheum. 1973 Nov-Dec;16(6):719–725. doi: 10.1002/art.1780160604. [DOI] [PubMed] [Google Scholar]
  2. Bach J. F., Dardenne M., Salomon J. C. Studies on thymus products. IV. Absence of serum 'thymic activity' in adult NZB and (NZB x NZW) F1 mice. Clin Exp Immunol. 1973 Jun;14(2):247–256. [PMC free article] [PubMed] [Google Scholar]
  3. Barthold D. R., Kysela S., Steinberg A. D. Decline in suppressor T cell function with age in female NZB mice. J Immunol. 1974 Jan;112(1):9–16. [PubMed] [Google Scholar]
  4. Cantor H., Asofsky R., Talal N. Synergy among lymphoid cells mediating the graft-versus-host response. I. Synergy in graft-versus-host reactions produced by cells from NZB-Bl mice. J Exp Med. 1970 Feb;131(2):223–234. doi: 10.1084/jem.131.2.223. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Dauphinee M. J., Talal N. Alteration in DNA synthetic response of thymocytes from NZB mice of different ages. Proc Natl Acad Sci U S A. 1973 Dec;70(12):3769–3772. doi: 10.1073/pnas.70.12.3769. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Denman A. M., Denman E. J. Depletion of long-lived lymphocytes in old New Zealand black mice. Clin Exp Immunol. 1970 Apr;6(4):457–472. [PMC free article] [PubMed] [Google Scholar]
  7. Dixon F. J., Oldstone M. B., Tonietti G. Pathogenesis of immune complex glomerulonephritis of New Zealand mice. J Exp Med. 1971 Sep 1;134(3 Pt 2):65s–71s. [PubMed] [Google Scholar]
  8. Gazdar A. F., Beitzel W., Talal N. The age related responses of New Zealand mice to a murine sarcoma virus. Clin Exp Immunol. 1971 Mar;8(3):501–509. [PMC free article] [PubMed] [Google Scholar]
  9. Greenspan J. S., Gutman G. A., Weissman I. L., Talal N. Thymus-antigen- and immunoglobulin-positive lymphocytes in tissue infiltrates of NZB/NZW mice. Clin Immunol Immunopathol. 1974 Sep;3(1):16–31. doi: 10.1016/0090-1229(74)90020-8. [DOI] [PubMed] [Google Scholar]
  10. HELYER B. J., HOWIE J. B. Renal disease associated with positive lupus erythematosus tests in a cross-bred strain of mice. Nature. 1963 Jan 12;197:197–197. doi: 10.1038/197197a0. [DOI] [PubMed] [Google Scholar]
  11. Jacobs M. E., Gordon J. K., Talal N. Inability of the NZB-NZW F 1 thymus to transfer cyclophosphamide-induced tolerance to sheep erythrocytes. J Immunol. 1971 Aug;107(2):359–364. [PubMed] [Google Scholar]
  12. Lambert P. H., Dixon F. J. Pathogenesis of the glomerulonephritis of NZB/W mice. J Exp Med. 1968 Mar 1;127(3):507–522. doi: 10.1084/jem.127.3.507. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Leventhal B. G., Talal N. Response of NZB and NZB-NZW spleen cells to mitogenic agents. J Immunol. 1970 Apr;104(4):918–923. [PubMed] [Google Scholar]
  14. Lies R. B., Messner R. P., Williams R. C., Jr Relative T-cell specificity of lymphocytotoxins from patients with systemic lupus erythematosus. Arthritis Rheum. 1973 May-Jun;16(3):369–375. doi: 10.1002/art.1780160312. [DOI] [PubMed] [Google Scholar]
  15. Mellors R. C. Autoimmune and immunoproliferative diseases of NZB/Bl mice and hybrids. Int Rev Exp Pathol. 1966;5:217–252. [PubMed] [Google Scholar]
  16. Mellors R. C., Huang C. Y. Immunopathology of NZB/BL mice. V. Viruslike (filtrable) agent separable from lymphoma cells and identifiable by electron microscopy. J Exp Med. 1966 Dec 1;124(6):1031–1038. doi: 10.1084/jem.124.6.1031. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Mittal K. K., Rossen R. D., Sharp J. T., Lidsky M. D., Butler W. T. Lymphocyte cytotoxic antibodies in systemic lupus erythematosus. Nature. 1970 Mar 28;225(5239):1255–1256. doi: 10.1038/2251255a0. [DOI] [PubMed] [Google Scholar]
  18. Parker L. M., Chused T. M., Steinberg A. D. Immunofluorescence studies on thymocytotoxic antibody from New Zealand Black mice. J Immunol. 1974 Jan;112(1):285–292. [PubMed] [Google Scholar]
  19. Playfair J. H. Strain differences in the immune responses of mice. 3. A raised tolerance threshold in NZB thymus cells. Immunology. 1971 Dec;21(6):1037–1043. [PMC free article] [PubMed] [Google Scholar]
  20. Schur P. H., Stollar B. D., Steinberg A. D., Talal N. Incidence of antibodies to double-stranded RNA in systemic lupus erythematosus and related diseases. Arthritis Rheum. 1971 May-Jun;14(3):342–347. doi: 10.1002/art.1780140304. [DOI] [PubMed] [Google Scholar]
  21. Shirai T., Mellors R. C. Natural cytotoxic autoantibody against thymocytes in NZB mice. Clin Exp Immunol. 1972 Sep;12(1):133–152. [PMC free article] [PubMed] [Google Scholar]
  22. Shirai T., Mellors R. C. Natural thymocytotoxic autoantibody and reactive antigen in New Zealand black and other mice. Proc Natl Acad Sci U S A. 1971 Jul;68(7):1412–1415. doi: 10.1073/pnas.68.7.1412. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Shirai T., Yoshiki T., Mellors R. C. Age-decrease of cells sensitive to an autoantibody-specific for thymocytes and thymus-dependent lymphocytes in NZB mice. Clin Exp Immunol. 1972 Dec;12(4):455–464. [PMC free article] [PubMed] [Google Scholar]
  24. Shirai T., Yoshiki T., Mellors R. C. Effects of natural thymocytotoxic autoantibody of NZB mice and of specifically prepared antilymphocyte serum on the tissue distribution of 51 Cr-labeled lymphocytes. J Immunol. 1973 Feb;110(2):517–523. [PubMed] [Google Scholar]
  25. Shirai T., Yoshiki T., Mellors R. C. Thymus dependence of cells in peripheral lymphoid tissues and in the circulation sensitive to natural thymocytotoxic autoantibody in NZB mice. J Immunol. 1972 Jul;109(1):32–37. [PubMed] [Google Scholar]
  26. Staples P. J., Talal N. Relative inability to induce tolerance in adult NZB and NZB-NZW F1 mice. J Exp Med. 1969 Jan 1;129(1):123–139. doi: 10.1084/jem.129.1.123. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. Steinberg A. D., Pincus T., Talal N. DNA-binding assay for detection of anti-DNA antibodies in NZB-NZW F1 mice. J Immunol. 1969 Mar;102(3):788–790. [PubMed] [Google Scholar]
  28. Sugai S., Pillarisetty R., Talal N. Monoclonal macroglobulinemia in NZB-NZW F1 mice. J Exp Med. 1973 Oct 1;138(4):989–1002. doi: 10.1084/jem.138.4.989. [DOI] [PMC free article] [PubMed] [Google Scholar]
  29. Talal N., Steinberg A. D., Daley G. G. Inhibition of antigodies binding polyinosinic-polycytidylic acid in human and mouse lupus sera by viral and synthetic ribonucleic acids. J Clin Invest. 1971 Jun;50(6):1248–1252. doi: 10.1172/JCI106602. [DOI] [PMC free article] [PubMed] [Google Scholar]
  30. Talal N., Steinberg A. D., Jacobs M. E., Chused T. M., Gazdar A. F. Immune cell cooperation, viruses, and antibodies to nucleic acids in New Zealand mice. J Exp Med. 1971 Sep 1;134(3 Pt 2):52s–64s. [PubMed] [Google Scholar]
  31. Terasaki P. I., Mottironi V. D., Barnett E. V. Cytotoxins in disease. Autocytotoxins in lupus. N Engl J Med. 1970 Oct 1;283(14):724–728. doi: 10.1056/NEJM197010012831403. [DOI] [PubMed] [Google Scholar]
  32. Zatz M. M., Mellors R. C., Lance E. M. Changes in lymphoid populations of ageing CBA and NZB mice. Clin Exp Immunol. 1971 Mar;8(3):491–500. [PMC free article] [PubMed] [Google Scholar]

Articles from Immunology are provided here courtesy of British Society for Immunology

RESOURCES