Abstract
Domestic fowl were found to be hypersensitive to a second injection of highly purified mineral oil if they had been primed 3 weeks previously with oil in the presence of mycobacteria. This response did not appear to be related to impurities originally present in the oil or introduced into it during sterilization, and did not follow priming with mycobacteria in vegetable oil or in saline. The reaction at the challenge site was prolonged and developed a characteristic histology identical to that found at the priming site. It is postualted that the hypersensitivity seen has an immunological basis and that birds are able to respond to antigenic determinants formed by long chain aliphatic hydrocarbons.
Full text
PDF
Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Baer H., Watkins R. C., Kurtz A. P., Byck J. S., Dawson C. R. Delayed contact sensitivity to catechols. 3. The relationship of side-chain length to sensitizing potency of catechols chemically related to the active principles of poison ivy. J Immunol. 1967 Aug;99(2):370–375. [PubMed] [Google Scholar]
- Baer H., Watkins R. C., Kurtz A. P., Byck J. S., Dawson C. R. Delayed contact sensitivity to catechols. II. Cutaneous toxicity of catechols chemically related to the active principles of poison ivy. J Immunol. 1967 Aug;99(2):365–369. [PubMed] [Google Scholar]
- Bollinger J. N. Metabolic fate of mineral oil adjuvants using 14C-labeled tracers. I. Mineral oil. J Pharm Sci. 1970 Aug;59(8):1084–1088. doi: 10.1002/jps.2600590804. [DOI] [PubMed] [Google Scholar]
- Inchiosa M. A., Jr Water-soluble extractives of disposable syringes. Nature and significance. J Pharm Sci. 1965 Sep;54(9):1379–1381. doi: 10.1002/jps.2600540934. [DOI] [PubMed] [Google Scholar]
- Kabat E. A. The nature of an antigenic determinant. J Immunol. 1966 Jul;97(1):1–11. [PubMed] [Google Scholar]
- Palmer P. E. Effects of instillation of paraffins in tissue. Lancet. 1973 Jul 21;2(7821):150–150. doi: 10.1016/s0140-6736(73)93092-4. [DOI] [PubMed] [Google Scholar]