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. 1975 Sep;29(3):543–548.

The genetic control of antibody affinity in mice.

F E Katz, M W Steward
PMCID: PMC1445959  PMID: 1165110

Abstract

Random-bred TO mice have been selectively bred into two lines on the basis of the relative affinity (KR) of antibody produced to protein antigens, one line producing high and the other low KR antibody. After four generations of selective breeding the difference in KR between the two lines was highly significant (P less than 0-001). The selection on the basis of KR did not result in a corresponding selection for antibody levels (Abt), which were not significantly different in the two lines. These results indicate that antibody affinity is a genetically controlled parameter of the immune response. Furthermore, this control appears to be expressed by a mechanism which is independent of the amount of antibody produced.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Alpers J. H., Steward M. W., Soothill J. F. Differences in immune elimination in inbred mice. The role of low affinity antibody. Clin Exp Immunol. 1972 Sep;12(1):121–132. [PMC free article] [PubMed] [Google Scholar]
  2. Benacerraf B., McDevitt H. O. Histocompatibility-linked immune response genes. Science. 1972 Jan 21;175(4019):273–279. doi: 10.1126/science.175.4019.273. [DOI] [PubMed] [Google Scholar]
  3. McDevitt H. O., Benacerraf B. Genetic control of specific immune responses. Adv Immunol. 1969;11:31–74. doi: 10.1016/s0065-2776(08)60477-0. [DOI] [PubMed] [Google Scholar]
  4. Oldstone M. B., Dixon F. J. Pathogenesis of chronic disease associated with persistent lymphocytic choriomeningitis viral infection. I. Relationship of antibody production to disease in neonatally infected mice. J Exp Med. 1969 Mar 1;129(3):483–505. doi: 10.1084/jem.129.3.483. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Passwell J. H., Steward M. W., Soothill J. F. Inter-mouse strain differences in macrophage function and its relationship to antibody responses. Clin Exp Immunol. 1974 May;17(1):159–167. [PMC free article] [PubMed] [Google Scholar]
  6. Petty R. E., Steward M. W. Relative affinity of anti-protein antibodies in New Zealand mice. Clin Exp Immunol. 1972 Nov;12(3):343–350. [PMC free article] [PubMed] [Google Scholar]
  7. Petty R. E., Steward M. W., Soothill J. F. The heterogeneity of antibody affinity in inbred mice and its possible immunopathologic significance. Clin Exp Immunol. 1972 Oct;12(2):231–241. [PMC free article] [PubMed] [Google Scholar]
  8. Soothill J. F., Steward M. W. The immunopathological significance of the heterogeneity of antibody affinity. Clin Exp Immunol. 1971 Aug;9(2):193–199. [PMC free article] [PubMed] [Google Scholar]
  9. Steward M. W., Katz F. E., West N. J. The role of low affinity antibody in immune complex disease. The quantity of anti-DNA antibodies in NZB/W F1 hybrid mice. Clin Exp Immunol. 1975 Jul;21(1):121–130. [PMC free article] [PubMed] [Google Scholar]
  10. Steward M. W., Petty R. E. The use of ammonium sulphate globulin precipitation for determination of affinity of anti-protein antibodies in mouse serum. Immunology. 1972 May;22(5):747–756. [PMC free article] [PubMed] [Google Scholar]
  11. Stutman O., Yunis E. J., Good R. A. Deficient immunologic functions of NZB mice. Proc Soc Exp Biol Med. 1968 Apr;127(4):1204–1207. doi: 10.3181/00379727-127-32910. [DOI] [PubMed] [Google Scholar]

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