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. 1975 Dec;29(6):1103–1110.

Autoimmune New Zealand mouse. Alterations in C3 receptors, complement-induced clumps and follicular adherence of immune complexes.

A Arnaiz-Villena, P Sheldon
PMCID: PMC1446009  PMID: 1193684

Abstract

Lymphocytes with free complement receptors are markedly diminished in autoimmune mice, probably as a reflection of a receptor blockage by immune complexes. There is also a slight decrease in Fc receptor-bearing cells and an increase in complement-induced clumps. These alterations may be related to a lack of immune complex fixation onto germinal centres and also may play a part in possible defects in T-B-cell co-operation, follicular localization of immune complexes and immune response control in autoimmune mice.

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Selected References

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  1. Allison A. C., Denman A. M., Barnes R. D. Cooperating and controlling functions of thymus-derived lymphocytes in relation to autoimmunity. Lancet. 1971 Jul 17;2(7716):135–140. doi: 10.1016/s0140-6736(71)92306-3. [DOI] [PubMed] [Google Scholar]
  2. Arnaiz-Villena A., Gyöngyössy M. I., Playfair J. H. Rosette formation by mouse lymphocytes. II. T-cell specificities in a CRL subpopulation. Clin Exp Immunol. 1974 Oct;18(2):177–186. [PMC free article] [PubMed] [Google Scholar]
  3. Arnaiz-Villena A., Roitt I. M. Complement-induced mixed aggregation of T and B lymphocytes and myeloid cells and the effect of adjuvant. Clin Exp Immunol. 1975 Jul;21(1):115–120. [PMC free article] [PubMed] [Google Scholar]
  4. Cantor H., Asofsky R., Talal N. Synergy among lymphoid cells mediating the graft-versus-host response. I. Synergy in graft-versus-host reactions produced by cells from NZB-Bl mice. J Exp Med. 1970 Feb;131(2):223–234. doi: 10.1084/jem.131.2.223. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Diener E., Feldmann M. Antibody-mediated suppression of the immune response in vitro. II. A new approach to the phenomenon of immunological tolerance. J Exp Med. 1970 Jul 1;132(1):31–43. doi: 10.1084/jem.132.1.31. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Eden A., Bianco C., Nussenzweig Mechanism of binding of soluble immune complexes to lymphocytes. Cell Immunol. 1973 Jun;7(3):459–473. doi: 10.1016/0008-8749(73)90210-4. [DOI] [PubMed] [Google Scholar]
  7. Eden A., Bianco C., Nussenzweig V., Mayer M. M. C3 split products inhibit the binding of antigen-antibody-complement complexes to B lymphocytes. J Immunol. 1973 May;110(5):1452–1453. [PubMed] [Google Scholar]
  8. Ezer G., Hayward A. R. Inhibition of complement-dependent lymphocyte rosette formation: a possible test for activated complement products. Eur J Immunol. 1974 Feb;4(2):148–150. doi: 10.1002/eji.1830040216. [DOI] [PubMed] [Google Scholar]
  9. Feldmann M., Diener E. Antibody-mediated suppression of the immune response in vitro. I. Evidence for a central effect. J Exp Med. 1970 Feb;131(2):247–274. doi: 10.1084/jem.131.2.247. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Kerbel R. S., Davies A. J. The possible biological significance of Fc receptors on mammalian lymphocytes and tumor cells. Cell. 1974 Oct;3(2):105–112. doi: 10.1016/0092-8674(74)90113-5. [DOI] [PubMed] [Google Scholar]
  11. Mellors R. C., Aoki T., Huebner R. J. Further implication of murine leukemia-like virs in the disorders of NZB mice. J Exp Med. 1969 May 1;129(5):1045–1062. doi: 10.1084/jem.129.5.1045. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. NUSSENZWEIG R. S., MERRYMAN C., BENACERRAF B. ELECTROPHORETIC SEPARATION AND PROPERTIES OF MOUSE ANTIHAPTEN ANTIBODIES INVOLVED IN PASSIVE CUTANEOUS ANAPHYLAXIS AND PASSIVE HEMOLYSIS. J Exp Med. 1964 Aug 1;120:315–328. doi: 10.1084/jem.120.2.315. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Papamichail M., Gutierrez C., Embling P., Johnson P., Holborow E. J., Pepys M. B. Complement dependence of localisation of aggregated IgG in germinal centres. Scand J Immunol. 1975;4(4):343–347. doi: 10.1111/j.1365-3083.1975.tb02635.x. [DOI] [PubMed] [Google Scholar]
  14. Pepys M. B. Complement-mediated mixed aggregation of murine spleen cells. Nature. 1974 May 3;249(452):51–53. doi: 10.1038/249051a0. [DOI] [PubMed] [Google Scholar]
  15. Pepys M. B. Role of complement in induction of the allergic response. Nat New Biol. 1972 May 31;237(74):157–159. doi: 10.1038/newbio237157a0. [DOI] [PubMed] [Google Scholar]
  16. Playfair J. H. Strain differences in the immune responses of mice. 3. A raised tolerance threshold in NZB thymus cells. Immunology. 1971 Dec;21(6):1037–1043. [PMC free article] [PubMed] [Google Scholar]
  17. Rajapakse D. A., Glynn L. E. A simplified chamber suitable for the capillary macrophage migration inhibition test and other similar tissue culture work. J Immunol Methods. 1975;8(1-2):195–197. doi: 10.1016/0022-1759(75)90096-4. [DOI] [PubMed] [Google Scholar]
  18. Sinclair N. R., Chan P. L. Relationship between antibody-mediated immunosuppression and tolerance induction. Nature. 1971 Nov 12;234(5324):104–105. doi: 10.1038/234104a0. [DOI] [PubMed] [Google Scholar]
  19. Soteriades-Vlachos C., Gyöngyössy M. I., Playfair J. H. Rosette formation by mouse lymphocytes. III. Receptors for immunoglobulin on normal and activated T cells. Clin Exp Immunol. 1974 Oct;18(2):187–192. [PMC free article] [PubMed] [Google Scholar]
  20. Talal N. Immunologic and viral factors in the pathogenesis of systemic lupus erythematosus. Arthritis Rheum. 1970 Nov-Dec;13(6):887–894. doi: 10.1002/art.1780130620. [DOI] [PubMed] [Google Scholar]

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