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. 2000 Feb;90(2):199–207. doi: 10.2105/ajph.90.2.199

Immunization and the American way: 4 childhood vaccines.

J P Baker 1
PMCID: PMC1446142  PMID: 10667180

Abstract

Childhood immunization constitutes one of the great success stories of American public health in the 20th century. This essay provides a historical examination of this topic through 4 particularly important examples: diphtheria, pertussis, polio, and measles. Each case study illustrates how new vaccines have posed unique challenges related to basic science, clinical trial methodology, medical ethics, and public acceptance. A brief comparison of each story to the experience of Great Britain, however, suggests an underlying unity connecting all 4 examples. Whereas the British led the way in introducing formal clinical trial methodology in the field of immunization development, the Americans excelled in the rapid translation of laboratory knowledge into strategies suitable for mass application. Although this distinction appears to have diminished in recent years, it offers insight into the sources of creativity underlying American vaccine development and the corresponding difficulties sometimes created for utilizing vaccines fruits rationally.

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Selected References

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  1. Benison S. International medical cooperation: Dr. Albert Sabin, live poliovirus vaccine and the Soviets. Bull Hist Med. 1982 Winter;56(4):460–483. [PubMed] [Google Scholar]
  2. Berk L. B. Polio vaccine trials of 1935. Trans Stud Coll Physicians Phila. 1989 Dec;11(4):321–336. [PubMed] [Google Scholar]
  3. Birch C. A. The Schick test. Bela Schick (1877-1967). Practitioner. 1973 Jun;210(260):843–844. [PubMed] [Google Scholar]
  4. Enders J. F., Weller T. H., Robbins F. C. Cultivation of the Lansing Strain of Poliomyelitis Virus in Cultures of Various Human Embryonic Tissues. Science. 1949 Jan 28;109(2822):85–87. doi: 10.1126/science.109.2822.85. [DOI] [PubMed] [Google Scholar]
  5. FRANCIS T., Jr, KORNS R. F., VOIGHT R. B., BOISEN M., HEMPHILL F. M., NAPIER J. A., TOLCHINSKY E. An evaluation of the 1954 poliomyelitis vaccine trials. Am J Public Health Nations Health. 1955 May;45(5 Pt 2):1–63. [PMC free article] [PubMed] [Google Scholar]
  6. Fulginiti V. A., Eller J. J., Downie A. W., Kempe C. H. Altered reactivity to measles virus. Atypical measles in children previously immunized with inactivated measles virus vaccines. JAMA. 1967 Dec 18;202(12):1075–1080. doi: 10.1001/jama.202.12.1075. [DOI] [PubMed] [Google Scholar]
  7. Hansen B. America's first medical breakthrough: how popular excitement about a French rabies cure in 1885 raised new expectations for medical progress. Am Hist Rev. 1998 Apr;103(2):373–418. [PubMed] [Google Scholar]
  8. Hilleman M. R. Past, present, and future of measles, mumps, and rubella virus vaccines. Pediatrics. 1992 Jul;90(1 Pt 2):149–153. [PubMed] [Google Scholar]
  9. KATZ S. L., ENDERS J. F., HOLLOWAY A. Studies on an attenuated measles-virus vaccine. II. Clinical, virologic and immunologic effects of vaccine in institutionalized children. N Engl J Med. 1960 Jul 28;263:159–161. doi: 10.1056/NEJM196007282630402. [DOI] [PubMed] [Google Scholar]
  10. KATZ S. L., KEMPE C. H., BLACK F. L., LEPOW M. L., KRUGMAN S., HAGGERTY R. J., ENDERS J. F. Studies on an attenuated measles-virus vaccine. VIII. General summary and evaluation of the results of vaccine. N Engl J Med. 1960 Jul 28;263:180–184. doi: 10.1056/NEJM196007282630408. [DOI] [PubMed] [Google Scholar]
  11. KRUGMAN S., GILES J. P., JACOBS A. M. Studies on an attenuated measles-virus vaccine. VI. Clinical, antigenic and prophylactic effects of vaccine in institutionalized children. N Engl J Med. 1960 Jul 28;263:174–177. doi: 10.1056/NEJM196007282630406. [DOI] [PubMed] [Google Scholar]
  12. Lewis J. The prevention of diphtheria in Canada and Britain 1914-1945. J Soc Hist. 1986;20(1):163–176. doi: 10.1353/jsh/20.1.163. [DOI] [PubMed] [Google Scholar]
  13. Miller C. L. Measles--the present status of vaccination. Practitioner. 1967 Nov;199(193):607–615. [PubMed] [Google Scholar]
  14. Park W. H., Zingher A. DIPHTHERIA IMMUNITY-NATURAL, ACTIVE AND PASSIVE. ITS DETERMINATION BY THE SCHICK TEST. Am J Public Health (N Y) 1916 May;6(5):431–445. doi: 10.2105/ajph.6.5.431-b. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Radetsky M. Smallpox: a history of its rise and fall. Pediatr Infect Dis J. 1999 Feb;18(2):85–93. doi: 10.1097/00006454-199902000-00002. [DOI] [PubMed] [Google Scholar]
  16. Sencer D. J. A program to eradicate measles. Am J Public Health Nations Health. 1967 May;57(5):729–730. doi: 10.2105/ajph.57.5.729-b. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Weller T. H., Robbins F. C. John Franklin Enders: February 10, 1897-September 8, 1985. Biogr Mem Natl Acad Sci. 1991;60:47–65. [PubMed] [Google Scholar]

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