Skip to main content
NCBI home page
CMAJ : Canadian Medical Association Journal logoLink to CMAJ : Canadian Medical Association Journal
. 1990 Feb 15;142(4):311–317.

Human papillomavirus and cervical intraepithelial neoplasia in women who subsequently had invasive cancer.

D Caussy 1, L D Marrett 1, A J Worth 1, M McBride 1, W E Rawls 1
PMCID: PMC1451821  PMID: 2154306

Abstract

In a retrospective case-control study biopsy specimens of cervical intraepithelial neoplasia (CIN) lesions from 47 women in whom invasive cancer subsequently developed (cases) and from 94 control subjects in whom CIN was diagnosed within 6 months of the diagnosis for the matched case subject but invasive disease did not develop were tested for human papillomavirus (HPV) DNA with tissue in-situ hybridization. There were no significant differences in the frequency of detection of HPV DNA between the two groups. In a cross-sectional survey the prevalence of HPV DNA was found to be 11% in specimens without CIN, 27% in those with CIN I, 49% in those with CIN II and 56% in those with CIN III. The positivity rates for HPV 16/33 DNA increased with the severity of CIN, but this was not observed for HPV 6/11 and 18 DNA. A comparison of the results of the case-control and cross-sectional studies suggested that the younger cohort of women had higher prevalence rates of HPV DNA than the older cohort.

Full text

PDF
311

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Beaudenon S., Kremsdorf D., Croissant O., Jablonska S., Wain-Hobson S., Orth G. A novel type of human papillomavirus associated with genital neoplasias. Nature. 1986 May 15;321(6067):246–249. doi: 10.1038/321246a0. [DOI] [PubMed] [Google Scholar]
  2. Boyes D. A., Worth A. J., Anderson G. H. Experience with cervical screening in British Columbia. Gynecol Oncol. 1981 Oct;12(2 Pt 2):S143–S155. doi: 10.1016/0090-8258(81)90070-6. [DOI] [PubMed] [Google Scholar]
  3. Brinton L. A., Fraumeni J. F., Jr Epidemiology of uterine cervical cancer. J Chronic Dis. 1986;39(12):1051–1065. doi: 10.1016/0021-9681(86)90139-6. [DOI] [PubMed] [Google Scholar]
  4. Brinton L. A., Hamman R. F., Huggins G. R., Lehman H. F., Levine R. S., Mallin K., Fraumeni J. F., Jr Sexual and reproductive risk factors for invasive squamous cell cervical cancer. J Natl Cancer Inst. 1987 Jul;79(1):23–30. [PubMed] [Google Scholar]
  5. Brinton L. A., Reeves W. C., Brenes M. M., Herrero R., de Britton R. C., Gaitan E., Tenorio F., Garcia M., Rawls W. E. Parity as a risk factor for cervical cancer. Am J Epidemiol. 1989 Sep;130(3):486–496. doi: 10.1093/oxfordjournals.aje.a115362. [DOI] [PubMed] [Google Scholar]
  6. Caussy D., Orr W., Daya A. D., Roth P., Reeves W., Rawls W. Evaluation of methods for detecting human papillomavirus deoxyribonucleotide sequences in clinical specimens. J Clin Microbiol. 1988 Feb;26(2):236–243. doi: 10.1128/jcm.26.2.236-243.1988. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Chuang T. Y., Perry H. O., Kurland L. T., Ilstrup D. M. Condyloma acuminatum in Rochester, Minn., 1950-1978. I. Epidemiology and clinical features. Arch Dermatol. 1984 Apr;120(4):469–475. [PubMed] [Google Scholar]
  8. Crum C. P., Nagai N., Levine R. U., Silverstein S. In situ hybridization analysis of HPV 16 DNA sequences in early cervical neoplasia. Am J Pathol. 1986 Apr;123(1):174–182. [PMC free article] [PubMed] [Google Scholar]
  9. FIDLER H. K., BOYES D. A., LOCK D. R. Intra-epithelial carcinoma of the cervix, 214 cases, with emphasis on investigation by cytology and cone biopsy. Can Med Assoc J. 1957 Jul 15;77(2):79–85. [PMC free article] [PubMed] [Google Scholar]
  10. Jussawalla D. J., Deshpande V. A., Standfast S. J. Assessment of risk patterns in cancer of the cervix: a comparison between greater Bombay and western countries. Int J Cancer. 1971 Mar 15;7(2):259–268. doi: 10.1002/ijc.2910070210. [DOI] [PubMed] [Google Scholar]
  11. Kessler I. I., Kulcar Z., Zimolo A., Grgurević M., Strnad M., Goodwin B. J. Cervical cancer in Yugoslavia. II. Epidemiologic factors of possible etiologic significance. J Natl Cancer Inst. 1974 Jul;53(1):51–60. doi: 10.1093/jnci/53.1.51. [DOI] [PubMed] [Google Scholar]
  12. King L. A., Tase T., Twiggs L. B., Okagaki T., Savage J. E., Adcock L. L., Prem K. A., Carson L. F. Prognostic significance of the presence of human papillomavirus DNA in patients with invasive carcinoma of the cervix. Cancer. 1989 Mar 1;63(5):897–900. doi: 10.1002/1097-0142(19890301)63:5<897::aid-cncr2820630517>3.0.co;2-w. [DOI] [PubMed] [Google Scholar]
  13. Kjaer S. K., de Villiers E. M., Haugaard B. J., Christensen R. B., Teisen C., Møller K. A., Poll P., Jensen H., Vestergaard B. F., Lynge E. Human papillomavirus, herpes simplex virus and cervical cancer incidence in Greenland and Denmark. A population-based cross-sectional study. Int J Cancer. 1988 Apr 15;41(4):518–524. doi: 10.1002/ijc.2910410408. [DOI] [PubMed] [Google Scholar]
  14. Matlashewski G., Schneider J., Banks L., Jones N., Murray A., Crawford L. Human papillomavirus type 16 DNA cooperates with activated ras in transforming primary cells. EMBO J. 1987 Jun;6(6):1741–1746. doi: 10.1002/j.1460-2075.1987.tb02426.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. McCance D. J., Clarkson P. K., Dyson J. L., Walker P. G., Singer A. Human papillomavirus types 6 and 16 in multifocal intraepithelial neoplasias of the female lower genital tract. Br J Obstet Gynaecol. 1985 Nov;92(11):1093–1100. doi: 10.1111/j.1471-0528.1985.tb03018.x. [DOI] [PubMed] [Google Scholar]
  16. Meanwell C. A., Cox M. F., Blackledge G., Maitland N. J. HPV 16 DNA in normal and malignant cervical epithelium: implications for the aetiology and behaviour of cervical neoplasia. Lancet. 1987 Mar 28;1(8535):703–707. doi: 10.1016/s0140-6736(87)90353-9. [DOI] [PubMed] [Google Scholar]
  17. Miller A. B. Screening for cancer: issues and future directions. J Chronic Dis. 1986;39(12):1067–1077. doi: 10.1016/0021-9681(86)90140-2. [DOI] [PubMed] [Google Scholar]
  18. Pater M. M., Dunne J., Hogan G., Ghatage P., Pater A. Human papillomavirus types 16 and 18 sequences in early cervical neoplasia. Virology. 1986 Nov;155(1):13–18. doi: 10.1016/0042-6822(86)90163-7. [DOI] [PubMed] [Google Scholar]
  19. Reeves W. C., Brinton L. A., García M., Brenes M. M., Herrero R., Gaitán E., Tenorio F., de Britton R. C., Rawls W. E. Human papillomavirus infection and cervical cancer in Latin America. N Engl J Med. 1989 Jun 1;320(22):1437–1441. doi: 10.1056/NEJM198906013202201. [DOI] [PubMed] [Google Scholar]
  20. Reeves W. C., Rawls W. E., Brinton L. A. Epidemiology of genital papillomaviruses and cervical cancer. Rev Infect Dis. 1989 May-Jun;11(3):426–439. doi: 10.1093/clinids/11.3.426. [DOI] [PubMed] [Google Scholar]
  21. Reid R., Greenberg M., Jenson A. B., Husain M., Willett J., Daoud Y., Temple G., Stanhope C. R., Sherman A. I., Phibbs G. D. Sexually transmitted papillomaviral infections. I. The anatomic distribution and pathologic grade of neoplastic lesions associated with different viral types. Am J Obstet Gynecol. 1987 Jan;156(1):212–222. doi: 10.1016/0002-9378(87)90241-9. [DOI] [PubMed] [Google Scholar]
  22. Richart R. M. Causes and management of cervical intraepithelial neoplasia. Cancer. 1987 Oct 15;60(8 Suppl):1951–1959. doi: 10.1002/1097-0142(19901015)60:8+<1951::aid-cncr2820601505>3.0.co;2-u. [DOI] [PubMed] [Google Scholar]
  23. Shibata D. K., Arnheim N., Martin W. J. Detection of human papilloma virus in paraffin-embedded tissue using the polymerase chain reaction. J Exp Med. 1988 Jan 1;167(1):225–230. doi: 10.1084/jem.167.1.225. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Syrjänen K., Mäntyjärvi R., Saarikoski S., Väyrynen M., Syrjänen S., Parkkinen S., Yliskoski M., Saastamoinen J., Castren O. Factors associated with progression of cervical human papillomavirus (HPV) infections into carcinoma in situ during a long-term prospective follow-up. Br J Obstet Gynaecol. 1988 Nov;95(11):1096–1102. doi: 10.1111/j.1471-0528.1988.tb06785.x. [DOI] [PubMed] [Google Scholar]
  25. de Villiers E. M., Wagner D., Schneider A., Wesch H., Miklaw H., Wahrendorf J., Papendick U., zur Hausen H. Human papillomavirus infections in women with and without abnormal cervical cytology. Lancet. 1987 Sep 26;2(8561):703–706. doi: 10.1016/s0140-6736(87)91072-5. [DOI] [PubMed] [Google Scholar]
  26. zur Hausen H. Genital papillomavirus infections. Prog Med Virol. 1985;32:15–21. [PubMed] [Google Scholar]

Articles from CMAJ: Canadian Medical Association Journal are provided here courtesy of Canadian Medical Association

RESOURCES