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. 1986 May;58(1):151–155.

Anti-acetylcholine receptor antibodies induced in mice by syngeneic receptor without adjuvants.

G K Scadding, L Calder, A Vincent, C Prior, D Wray, J Newsom-Davis
PMCID: PMC1452621  PMID: 3486818

Abstract

Acetylcholine receptor (AChR)-bearing membranes from the BC3H-1 cell lines were injected, without adjuvant, either intrathymically (i.t.) followed by intraperitoneal (i.p.) booster doses, or i.p. alone, into (C57BL X BALB/c)F1 mice. Over 75% of the animals developed serum anti-AChRs which reacted with the cell-line AChR and with normal mouse endplate AChR. The titres were within the lower range of those of myasthenia gravis patients, and some mice showed reduced miniature endplate potential (m.e.p.p) amplitudes. these results indicate that loss of tolerance to acetylcholine receptors can result from immunization against syngeneic AChR without adjuvant. This approach may provide a useful model for studying mechanisms of autoimmunity against acetylcholine receptor.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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