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. 1986 Jun;58(2):217–223.

Investigation of antigen cross-reactivity of Mycobacterium leprae-reactive murine T-cell lines and clones.

A E Kingston, A J Stagg, M J Colston
PMCID: PMC1452672  PMID: 2423443

Abstract

Inguinal lymph node lymphocytes from BALB/c mice immunized intradermally with 10(8) 60Co-irradiated Mycobacterium leprae were cloned by limiting dilution culture. In general, cloned T-cell lines exhibited helper type activity producing interleukin-2, macrophage activation factor and gamma-interferon and lines were further characterized in terms of their cross-reactivities with other species of mycobacteria. M. leprae clones derived after a period of in vitro restimulation were found to cross-react with other species of mycobacteria probably recognizing non-specific or closely related common cell wall associated mycobacterial determinants. On the other hand, lines established by cloning directly from immune mice appeared more M. leprae-specific, exhibiting antigen-dependent lymphokine production and proliferation in vitro.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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