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. 1986 Nov;59(3):445–450.

Immunological defects in SJL mice.

P R Hutchings, A M Varey, A Cooke
PMCID: PMC1453197  PMID: 2947846

Abstract

SJL mice are shown to be defective in their ability to develop suppressor cells following stimulation with Con A, a polyclonal T-cell activator. They make a normal proliferative response to this mitogen. In addition to this suppressor T-cell defect, the SJL mouse (unlike most mouse strains) does not develop a spontaneous antibody response to bromelain-treated autologous red blood cells (BrMRBC) in vitro. Although the SJL makes a normal proliferative response to LPS, antibody-forming cells against bromelain-treated autologous red blood cells are not increased following LPS in vivo nor does it manifest an increased response to SRBC or TNP. This may signify the presence of a functional B-cell defect in these animals. DBA mice are also shown, in this report, to have small numbers of antibody-forming cells to bromelain-treated autologous red blood cells but to be capable of responding to LPS in vivo with an increase in SRBC and TNP antibody responses.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Amagai T., Cinader B. Resistance against tolerance induction in SJL mice. Immunol Commun. 1981;10(4-5):349–358. doi: 10.3109/08820138109050700. [DOI] [PubMed] [Google Scholar]
  2. Brown A. M., McFarlin D. E. Relapsing experimental allergic encephalomyelitis in the SJL/J mouse. Lab Invest. 1981 Sep;45(3):278–284. [PubMed] [Google Scholar]
  3. Cooke A., Hutchings P. Defective regulation of erythrocyte autoantibodies in SJL mice. Immunology. 1984 Mar;51(3):489–492. [PMC free article] [PubMed] [Google Scholar]
  4. Cox K. O., Evans D., Brooks D., Cunliffe D. A. In vitro investigation of autoantibody-secreting peritoneal cells and their regulation. Immunology. 1979 Oct;38(2):355–365. [PMC free article] [PubMed] [Google Scholar]
  5. Cunningham A. J. Active suppressor mechanism maintaining tolerance to some self components. Nature. 1975 Mar 13;254(5496):143–144. doi: 10.1038/254143a0. [DOI] [PubMed] [Google Scholar]
  6. Cunningham A. J. Large numbers of cells in normal mice produce antibody components of isologous erythrocytes. Nature. 1974 Dec 20;252(5485):749–751. doi: 10.1038/252749a0. [DOI] [PubMed] [Google Scholar]
  7. Cunningham A. J., Szenberg A. Further improvements in the plaque technique for detecting single antibody-forming cells. Immunology. 1968 Apr;14(4):599–600. [PMC free article] [PubMed] [Google Scholar]
  8. Dresser D. W. Quantitative inheritance of heterophile rheumatoid factor responsiveness in mice. J Immunogenet. 1982 Feb;9(1):31–42. doi: 10.1111/j.1744-313x.1982.tb00780.x. [DOI] [PubMed] [Google Scholar]
  9. Dutton R. W. Inhibitory and stimulatory effects of concanavalin A on the response of mouse spleen cell suspensions to antigen. II. Evidence for separate stimulatory and inhibitory cells. J Exp Med. 1973 Dec 1;138(6):1496–1505. doi: 10.1084/jem.138.6.1496. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Ford R. J., Ruppert B., Maizel A. L. SJL tumor: a neoplasm involving macrophages. Lab Invest. 1981 Aug;45(2):111–119. [PubMed] [Google Scholar]
  11. Geckeler W., Blomberg B., de Preval C., Cohn M. On the genetic dissection of a specific humoral immune response to alpha(1,3) dextran. Cold Spring Harb Symp Quant Biol. 1977;41(Pt 2):743–748. doi: 10.1101/sqb.1977.041.01.085. [DOI] [PubMed] [Google Scholar]
  12. Goodman M. G., Weigle W. O. Dissociation of inductive from differentiative signals transmitted by C8-substituted guanine ribonucleosides to B cells from SJL mice. J Immunol. 1985 Jan;134(1):91–94. [PubMed] [Google Scholar]
  13. Hayakawa K., Hardy R. R., Honda M., Herzenberg L. A., Steinberg A. D., Herzenberg L. A. Ly-1 B cells: functionally distinct lymphocytes that secrete IgM autoantibodies. Proc Natl Acad Sci U S A. 1984 Apr;81(8):2494–2498. doi: 10.1073/pnas.81.8.2494. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Jayawardena A. N., Janeway C. A., Jr, Kemp J. D. Experimental malaria in the CBA/N mouse. J Immunol. 1979 Dec;123(6):2532–2539. [PubMed] [Google Scholar]
  15. Marshall-Clarke S., Cooke A., Hutchings P. R. Deficient production of anti-red cell autoantibodies by mice with an X-linked B lymphocyte defect. Eur J Immunol. 1979 Oct;9(10):820–823. doi: 10.1002/eji.1830091014. [DOI] [PubMed] [Google Scholar]
  16. McIntire K. R., Law L. W. Abnormal serum immunoglobulins occurring with reticular neoplasms in a inbred strain of mouse. J Natl Cancer Inst. 1967 Dec;39(6):1197–1211. [PubMed] [Google Scholar]
  17. Pages J., Bussard A. E. Precommitment of normal mouse peritoneal cells by erythrocyte antigens in relation to auto-antibody production. Nature. 1975 Sep 25;257(5524):316–317. doi: 10.1038/257316a0. [DOI] [PubMed] [Google Scholar]
  18. Pages J., Poncet P., Serban D., Witz I., Bussard A. E. Relationship between choline derivatives and mouse erythrocyte membrane antigens revealed by mouse monoclonal antibodies. I. Anticholine activity of anti-mouse erythrocyte monoclonal antibodies. Immunol Lett. 1982 Sep;5(3):167–173. doi: 10.1016/0165-2478(82)90103-1. [DOI] [PubMed] [Google Scholar]
  19. Poncet P., Kocher H. P., Pages J., Jaton J. C., Bussard A. E. Monoclonal autoantibodies against mouse red blood cells: a family of structurally restricted molecules. Mol Immunol. 1985 May;22(5):541–551. doi: 10.1016/0161-5890(85)90177-4. [DOI] [PubMed] [Google Scholar]
  20. Rich R. R., Pierce C. W. Biological expressions of lymphocyte activation. II. Generation of a population of thymus-derived suppressor lymphocytes. J Exp Med. 1973 Mar 1;137(3):649–659. doi: 10.1084/jem.137.3.649. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Rittenberg M. B., Pratt K. L. Antitrinitrophenyl (TNP) plaque assay. Primary response of Balb/c mice to soluble and particulate immunogen. Proc Soc Exp Biol Med. 1969 Nov;132(2):575–581. doi: 10.3181/00379727-132-34264. [DOI] [PubMed] [Google Scholar]
  22. Skidmore B. J., Chiller J. M., Morrison D. C., Weigle W. O. Immunologic properties of bacterial lipopolysaccharide (LPS): correlation between the mitogenic, adjuvant, and immunogenic activities. J Immunol. 1975 Feb;114(2 Pt 2):770–775. [PubMed] [Google Scholar]
  23. Vladutiu A. O., Rose N. R. Autoimmune murine thyroiditis relation to histocompatibility (H-2) type. Science. 1971 Dec 10;174(4014):1137–1139. doi: 10.1126/science.174.4014.1137. [DOI] [PubMed] [Google Scholar]

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