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. 1987 Feb;60(2):209–212.

Inositol lipid metabolism in human T lymphocytes activated via the T3 complex.

S Cockcroft, J R Lamb, E D Zanders
PMCID: PMC1453213  PMID: 2950051

Abstract

Cloned human T lymphocytes and a mitogenic monoclonal antibody (UCHT1) that binds to the T3 antigen complex were used to study the role of inositol lipid hydrolysis in T-cell activation. Binding of the T3 molecular complex with anti-T3 antibody induced the generation of inositol trisphosphate after a lag of 1 min. While this is commensurate with the rise in cytosolic Ca2+ in these cells, examination of the inositol lipid revealed that phosphorylation of phosphatidylinositol 4-phosphate to phosphatidylinositol 4,5-bisphosphate occurred before the generation of inositol trisphosphate. Thus, activation of an inositol lipid kinase appears to be one of the primary signals in cellular activation in human T lymphocytes.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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