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. 1987 Feb;60(2):275–280.

Specific stimulation of lymphocytes from patients with AIDS by herpes simplex virus antigens.

M A Wainberg, J Portnoy, C Tsoukas, N Gilmore
PMCID: PMC1453232  PMID: 3028941

Abstract

Peripheral blood lymphocytes of patients with AIDS are generally anergic to stimulation by lectins or by alloantigens. We have succeeded in demonstrating that the lymphocytes of six AIDS patients, with histories of herpes simplex virus (HSV)-induced genital, anal and/or oral lesions, retained functional specificity with regard to HSV antigens. This was accomplished by treating patient lymphocytes with OKT8 monoclonal antibodies, in the presence of complement, to yield a cell population that was partially responsive to phytohaemagglutinin (PHA). Enhanced proliferation was obtained in the presence of exogenous interleukin-2, which was also employed to foster the growth of these cells over several generations. Lymphocytes derived from these AIDS patients, and maintained in vitro as described, were specifically stimulated in proliferation assays by a HSV antigen preparation in six of the ten cases studied.

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Selected References

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  1. Barré-Sinoussi F., Chermann J. C., Rey F., Nugeyre M. T., Chamaret S., Gruest J., Dauguet C., Axler-Blin C., Vézinet-Brun F., Rouzioux C. Isolation of a T-lymphotropic retrovirus from a patient at risk for acquired immune deficiency syndrome (AIDS). Science. 1983 May 20;220(4599):868–871. doi: 10.1126/science.6189183. [DOI] [PubMed] [Google Scholar]
  2. Cantrell D. A., Smith K. A. The interleukin-2 T-cell system: a new cell growth model. Science. 1984 Jun 22;224(4655):1312–1316. doi: 10.1126/science.6427923. [DOI] [PubMed] [Google Scholar]
  3. Curran J. W., Lawrence D. N., Jaffe H., Kaplan J. E., Zyla L. D., Chamberland M., Weinstein R., Lui K. J., Schonberger L. B., Spira T. J. Acquired immunodeficiency syndrome (AIDS) associated with transfusions. N Engl J Med. 1984 Jan 12;310(2):69–75. doi: 10.1056/NEJM198401123100201. [DOI] [PubMed] [Google Scholar]
  4. Farmer J. L., Gottlieb A. A., Nishihara T. Inhibition of interleukin 2 production and expression of the interleukin 2 receptor by plasma from acquired immune deficiency syndrome patients. Clin Immunol Immunopathol. 1986 Feb;38(2):235–243. doi: 10.1016/0090-1229(86)90141-8. [DOI] [PubMed] [Google Scholar]
  5. Gallo R. C., Salahuddin S. Z., Popovic M., Shearer G. M., Kaplan M., Haynes B. F., Palker T. J., Redfield R., Oleske J., Safai B. Frequent detection and isolation of cytopathic retroviruses (HTLV-III) from patients with AIDS and at risk for AIDS. Science. 1984 May 4;224(4648):500–503. doi: 10.1126/science.6200936. [DOI] [PubMed] [Google Scholar]
  6. Groopman J. E., Salahuddin S. Z., Sarngadharan M. G., Markham P. D., Gonda M., Sliski A., Gallo R. C. HTLV-III in saliva of people with AIDS-related complex and healthy homosexual men at risk for AIDS. Science. 1984 Oct 26;226(4673):447–449. doi: 10.1126/science.6093247. [DOI] [PubMed] [Google Scholar]
  7. Levy J. A., Tobler L. H., McHugh T. M., Casavant C. H., Stites D. P. Long-term cultivation of T-cell subsets from patients with acquired immune deficiency syndrome. Clin Immunol Immunopathol. 1985 Jun;35(3):328–336. doi: 10.1016/0090-1229(85)90093-5. [DOI] [PubMed] [Google Scholar]
  8. Margolese R. G., Israel E., Wainberg M. A. Non-specific inhibition by virus particles of human lymphocytes mitogenesis. Clin Exp Immunol. 1980 Aug;41(2):243–251. [PMC free article] [PubMed] [Google Scholar]
  9. Marmor M., Friedman-Kien A. E., Zolla-Pazner S., Stahl R. E., Rubinstein P., Laubenstein L., William D. C., Klein R. J., Spigland I. Kaposi's sarcoma in homosexual men. A seroepidemiologic case-control study. Ann Intern Med. 1984 Jun;100(6):809–815. doi: 10.7326/0003-4819-100-6-809. [DOI] [PubMed] [Google Scholar]
  10. Popovic M., Sarngadharan M. G., Read E., Gallo R. C. Detection, isolation, and continuous production of cytopathic retroviruses (HTLV-III) from patients with AIDS and pre-AIDS. Science. 1984 May 4;224(4648):497–500. doi: 10.1126/science.6200935. [DOI] [PubMed] [Google Scholar]
  11. Rosen F. S. The acquired immunodeficiency syndrome (AIDS). J Clin Invest. 1985 Jan;75(1):1–3. doi: 10.1172/JCI111659. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Seligmann M., Chess L., Fahey J. L., Fauci A. S., Lachmann P. J., L'Age-Stehr J., Ngu J., Pinching A. J., Rosen F. S., Spira T. J. AIDS--an immunologic reevaluation. N Engl J Med. 1984 Nov 15;311(20):1286–1292. doi: 10.1056/NEJM198411153112005. [DOI] [PubMed] [Google Scholar]
  13. Sinkovics J. G., Gyorkey F., Melnick J. L., Gyorkey P. Acquired immune deficiency syndrome (AIDS): speculations about its etiology and comparative immunology. Rev Infect Dis. 1984 Sep-Oct;6(5):745–760. doi: 10.1093/clinids/6.5.745. [DOI] [PubMed] [Google Scholar]
  14. Wainberg M. A., Portnoy J. D., Clecner B., Hubschman S., Lagacé-Simard J., Rabinovitch N., Remer Z., Mendelson J. Viral inhibition of lymphocyte proliferative responsiveness in patients suffering from recurrent lesions caused by herpes simplex virus. J Infect Dis. 1985 Sep;152(3):441–448. doi: 10.1093/infdis/152.3.441. [DOI] [PubMed] [Google Scholar]

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