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. 1987 Jan;60(1):71–74.

Memory suppressor T cells in latent Japanese encephalitis virus infection.

A Mathur, R Kulshreshtha, S Rawat, U C Chaturvedi
PMCID: PMC1453365  PMID: 2434414

Abstract

The generation of secondary suppressor T (Ts) cells has been studied during latent Japanese encephalitis virus (JEV) infection of mice. The mice infected with JEV 27 weeks earlier, on challenge with the homologous virus, showed accelerated generation of secondary Ts cells; these appeared on Day 6, with peak activity on Day 8, and lasted for 27 days. The secondary Ts cells were Thy1.2+, Ly1-2+, antigen-specific, and acted in a dose-dependent manner. The secondary Ts cells could also be generated by reactivation of the JEV in latently infected mice. The findings thus show the presence of memory suppressor T cells in mice latently infected with JEV that can be stimulated to produce secondary Ts cells by exogenous or endogenous virus challenge. This phenomenon could help to persistence of the virus.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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