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. 1987 Jun;61(2):185–188.

Experimental studies of immunologically mediated enteropathy. III. Severe and progressive enteropathy during a graft-versus-host reaction in athymic mice.

A M Mowat, M V Felstein, M E Baca
PMCID: PMC1453370  PMID: 3496272

Abstract

The graft-versus-host reaction (GvHR) in unirradiated (CBA X BALB/c)F1 mice normally produces a proliferative enteropathy consisting of crypt hyperplasia and increased numbers of intraepithelial lymphocytes (IEL), but villus atrophy does not occur. Host T lymphocytes can protect animals from the consequences of a GvHR and, in this study, it is shown that athymic (CBA X BALB/c)F1 mice suffer a more severe systemic GvHR than intact hosts, with the unusual feature of specific anti-host cytotoxic T-lymphocyte (CTL) activity. In addition, nude mice not only had more intense crypt hyperplasia in the small intestine, but also had significant villus atrophy. It is concluded that host T cells normally prevent the progression of GvHR in unirradiated animals, and suggested that villus atrophy reflects a more severe form of the delayed-type hypersensitivity (DTH) reaction, the effects of which are normally limited to crypt hyperplasia.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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