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. 1987 Aug;61(4):457–461.

Dendritic cells from human tissues express receptors for the immunoregulatory vitamin D3 metabolite, dihydroxycholecalciferol.

A Brennan 1, D R Katz 1, J D Nunn 1, S Barker 1, M Hewison 1, L J Fraher 1, J L O'Riordan 1
PMCID: PMC1453440  PMID: 2832307

Abstract

Dendritic cells have been isolated from human tonsillar tissue and shown to act as accessory cells in a mitogenic response. The dendritic cells will induced receptors for the active metabolite of vitamin D3, 1,25(OH)2D3, in the responder E+ T cells. The dendritic cells themselves constitutively express receptors for the metabolite, and this distinguishes them from other non-T cells in lymphomedullary tissue. Expression of the 1,25(OH)2D3 receptor may be a dendritic cell property that facilitates their accessory cell role within the tissue microenvironment.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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